1-Benzyl-5-thiomorpholinosulfonyl Isatin

Base Information

• Chemical Name: 1-Benzyl-5-thiomorpholinosulfonyl Isatin
• CAS No.: 1144853-50-8
• Molecular Formula: C19H17N2O5S2
• Molecular Weight: 417.47868
• Mol file: 1144853-50-8.mol

Synonyms:1-Benzyl-5-thiomorpholinosulfonyl Isatin;1-(PhenylMethyl)-5-(4-thioMorpholinylsulfonyl)-1H-indole-2,3-dione;1-Benzyl-5-thioMorpholinosulfonyl-1H-indole-2,3-dione

Chemical Property of 1-Benzyl-5-thiomorpholinosulfonyl Isatin

Chemical Property:

• Melting Point: 224.1-224.9 °C
• Boiling Point: 650.6±65.0 °C(Predicted)
• PKA: -6.17±0.20(Predicted)
• PSA: 108.44000
• Density: 1.459±0.06 g/cm3(Predicted)
• LogP: 3.23730
• Storage Temp.: Refrigerator
• Solubility.: Dichloromethane, Ethyl Acetate, Methanol

Purity/Quality:

97% ^*data from raw suppliers

1-Benzyl-5-thiomorpholinosulfonylIsatin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Benzyl-5-thiomorpholinosulfonyl Isatin

There total 1 articles about 1-Benzyl-5-thiomorpholinosulfonyl Isatin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

5-(thiomorpholine-4-sulfonyl)indoline-2,3-dione (1144853-48-4) + benzyl bromide (100-39-0) → 1-benzyl-5-(thiomorpholine-4-sulfonyl)indoline-2,3-dione (1144853-50-8)

Guidance literature:

5-(thiomorpholine-4-sulfonyl)indoline-2,3-dione; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.25h; Inert atmosphere;

benzyl bromide; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jm900135r

Reference yield: 34.0%

1-benzyl-5-(thiomorpholine-4-sulfonyl)indoline-2,3-dione (1144853-50-8) + malononitrile (109-77-3) → 2-(1-benzyl-2-oxo-5-(thiomorpholine-4-sulfonyl)indolin-3-ylidene)malononitrile (1144853-53-1)

Guidance literature:

In methanol; for 0.5h; Reflux; Inert atmosphere;

DOI:10.1021/jm900135r

upstream raw materials:

5-(thiomorpholine-4-sulfonyl)indoline-2,3-dione

benzyl bromide

Downstream raw materials:

2-(1-benzyl-2-oxo-5-(thiomorpholine-4-sulfonyl)indolin-3-ylidene)malononitrile

Refernces