2-tert-butyl-4,5-diiodo-1-Methyl-1H-iMidazole

Base Information

• Chemical Name: 2-tert-butyl-4,5-diiodo-1-Methyl-1H-iMidazole
• CAS No.: 936731-45-2
• Molecular Formula: C₈H₁₂I₂N₂
• Molecular Weight: 390.006
• Mol file: 936731-45-2.mol

Synonyms:2-tert-butyl-4,5-diiodo-1-Methyl-1H-iMidazole;2-t-buty-4,5-diiodo-1-methyl-1H-imidazole;1-methyl-4,5-diiodo-2-tert-butylimidazole

Chemical Property of 2-tert-butyl-4,5-diiodo-1-Methyl-1H-iMidazole

Chemical Property:

• Boiling Point: 371.8±27.0 °C(Predicted)
• PKA: 3.69±0.60(Predicted)
• PSA: 17.82000
• Density: 2.10±0.1 g/cm3(Predicted)
• LogP: 2.92680

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-tert-butyl-4,5-diiodo-1-Methyl-1H-iMidazole

There total 3 articles about 2-tert-butyl-4,5-diiodo-1-Methyl-1H-iMidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4,5-diiodo-2-tert-butylimidazole (885019-81-8) + methyl iodide (74-88-4) → 1-methyl-4,5-diiodo-2-tert-butylimidazole (936731-45-2)

Guidance literature:

4,5-diiodo-2-tert-butylimidazole; With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 1h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.jorganchem.2011.10.006

Reference yield: 84.0%

1-methyl-2-tert-butylimidazole → 1-methyl-4,5-diiodo-2-tert-butylimidazole (936731-45-2)

Guidance literature:

With N-iodo-succinimide; In N,N-dimethyl-formamide; at 90 ℃; for 18h;

Reference yield:

2-(1,1-dimethylethyl)-1H-imidazole (36947-69-0) → 1-methyl-4,5-diiodo-2-tert-butylimidazole (936731-45-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: iodine; potassium iodide; sodium hydroxide / water / 20 °C / Inert atmosphere

2.1: potassium tert-butylate / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2.2: 0 - 20 °C / Inert atmosphere

With potassium tert-butylate; iodine; potassium iodide; sodium hydroxide; In tetrahydrofuran; water;

DOI:10.1016/j.jorganchem.2011.10.006

upstream raw materials:

4,5-diiodo-2-tert-butylimidazole

methyl iodide

2-(1,1-dimethylethyl)-1H-imidazole

Refernces

• 1、 -. "CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS". Page/Page column 61. . Retrieved 2010/11/27.