m-(TRIFLUOROMETHYL)PHENYLTRIMETHOXYSILANE

Base Information

• Chemical Name: m-(TRIFLUOROMETHYL)PHENYLTRIMETHOXYSILANE
• CAS No.: 53883-59-3
• Molecular Formula: C10H13F3O3Si
• Molecular Weight: 266.29
• Mol file: 53883-59-3.mol

Synonyms:m-(TRIFLUOROMETHYL)PHENYLTRIMETHOXYSILANE

Chemical Property of m-(TRIFLUOROMETHYL)PHENYLTRIMETHOXYSILANE

Chemical Property:

• Vapor Pressure: 0.323mmHg at 25°C
• Boiling Point: 207.5°C at 760 mmHg
• Flash Point: 79.3°C
• Density: 1.17g/cm³

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of m-(TRIFLUOROMETHYL)PHENYLTRIMETHOXYSILANE

There total 1 articles about m-(TRIFLUOROMETHYL)PHENYLTRIMETHOXYSILANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tetramethylorthosilicate (681-84-5) → trimethoxy-(3-trifluoromethyl-phenyl)-silane (53883-59-3)

Guidance literature:

In tetrahydrofuran; at -30 - 20 ℃; for 13h; Inert atmosphere;

DOI:10.1021/acs.orglett.0c00631

Reference yield: 73.0%

N-(2-pyrimidyl)indole (221044-05-9) + trimethoxy-(3-trifluoromethyl-phenyl)-silane (53883-59-3) → 1-(pyrimidin-2-yl)-2-(3-(trifluoromethyl)phenyl)-1H-indole

Guidance literature:

With copper (II)-fluoride; oxygen; cobalt(III) acetylacetonate; In toluene; at 160 ℃; for 24h; under 760.051 Torr; Sealed tube;

DOI:10.1021/acs.orglett.0c00631

Reference yield: 72.0%

N-(quinolin-8-yl)but‐3‐enamide + trimethoxy-(3-trifluoromethyl-phenyl)-silane (53883-59-3) → N-(quinolin-8-yl)-4-(3-(trifluoromethyl)phenyl)butanamide

Guidance literature:

With copper (II)-fluoride; water; palladium diacetate; In tetrahydrofuran; at 100 ℃; for 24h; regioselective reaction; Sealed tube;

DOI:10.1021/acs.orglett.0c03416

upstream raw materials:

tetramethylorthosilicate

Downstream raw materials:

m-trifluoromethylphenylsilatranone

Refernces

• 1、 Lu, Ming-Zhu,Loh, Teck-Peng,Luo, Haiqing,Hu, Zhengsong,Shao, Changdong,Kan, Yuhe. "Directed palladium(II)-catalyzed intermolecular anti-markovnikov hydroarylation of unactivated alkenes with (hetero)arylsilanes". supporting information. p. 9022 - 9028. Retrieved 2020/12/02.