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CAS

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221044-05-9

1-(pyrimidin-2-yl)-1H-indole, also known as GW-405833, is a chemical compound belonging to the indole class. It is a potent and selective inhibitor of the enzyme p38 mitogen-activated protein kinase (MAPK), which plays a crucial role in regulating immune and inflammatory responses. 1-(pyrimidin-2-yl)-1H-indole has been studied for its potential therapeutic applications in the treatment of inflammatory diseases and has shown inhibitory effects on the production of pro-inflammatory cytokines, making it a promising candidate for the development of new anti-inflammatory drugs.

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  • 221044-05-9 Structure

  • Basic information

    1. Product Name: 1-(pyrimidin-2-yl)-1H-indole
    2. Synonyms: 1-(pyrimidin-2-yl)-1H-indole;1-(2-Pyrimidinyl)indole;1-(Pyrimidin-2-yl)indole;2-(1H-Indol-1-yl)pyrimidine;N-(2-Pyrimidinyl)indole;1-(2-Pyrimidinyl)-1H-indole
    3. CAS NO:221044-05-9
    4. Molecular Formula: C12H9N3
    5. Molecular Weight: 195.21996
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 221044-05-9.mol

  • Chemical Properties

    1. Melting Point: 83.0 to 87.0 °C
    2. Boiling Point: 412.2±28.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.21±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 0.96±0.33(Predicted)
    10. CAS DataBase Reference: 1-(pyrimidin-2-yl)-1H-indole(CAS DataBase Reference)
    11. NIST Chemistry Reference: 1-(pyrimidin-2-yl)-1H-indole(221044-05-9)
    12. EPA Substance Registry System: 1-(pyrimidin-2-yl)-1H-indole(221044-05-9)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 221044-05-9(Hazardous Substances Data)

221044-05-9 Usage

Uses

Used in Pharmaceutical Industry:
1-(pyrimidin-2-yl)-1H-indole is used as a therapeutic agent for the treatment of inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease. Its ability to selectively inhibit the p38 MAPK enzyme helps in reducing inflammation and alleviating the symptoms associated with these conditions.
Used in Anti-inflammatory Drug Development:
1-(pyrimidin-2-yl)-1H-indole is used as a lead compound in the development of new anti-inflammatory drugs. Its inhibitory effects on the production of pro-inflammatory cytokines make it a valuable asset in the search for more effective and targeted treatments for various inflammatory disorders.
Used in Research and Development:
1-(pyrimidin-2-yl)-1H-indole is used as a research tool in the study of the p38 MAPK pathway and its role in immune and inflammatory responses. It aids in understanding the molecular mechanisms underlying these processes and helps in the identification of potential therapeutic targets for the treatment of related diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 221044-05-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,1,0,4 and 4 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 221044-05:
(8*2)+(7*2)+(6*1)+(5*0)+(4*4)+(3*4)+(2*0)+(1*5)=69
69 % 10 = 9
So 221044-05-9 is a valid CAS Registry Number.

221044-05-9Relevant articles and documents

Cobalt-catalyzed intramolecular decarbonylative coupling of acylindoles and diarylketones through the cleavage of C-C bonds

Lu, Hong,Wei, Hao,Xu, Wen-Hua,Yu, Tian-Yang

, p. 12336 - 12340 (2020/12/08)

We report here cobalt-N-heterocyclic carbene catalytic systems for the intramolecular decarbonylative coupling through the chelation-assisted C-C bond cleavage of acylindoles and diarylketones. The reaction tolerates a wide range of functional groups such as alkyl, aryl, and heteroaryl groups, giving the decarbonylative products in moderate to excellent yields. This transformation involves the cleavage of two C-C bonds and formation of a new C-C bond without the use of noble metals, thus reinforcing the potential application of decarbonylation as an effective tool for C-C bond formation. This journal is

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