221044-05-9 Usage
General Description
1-(pyrimidin-2-yl)-1H-indole, also known as GW-405833, is a chemical compound belonging to the indole class. It is a potent and selective inhibitor of the enzyme p38 mitogen-activated protein kinase (MAPK), which is involved in regulating immune and inflammatory responses. 1-(pyrimidin-2-yl)-1H-indole has been studied for its potential therapeutic applications in the treatment of inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease. Research has also shown that 1-(pyrimidin-2-yl)-1H-indole may have inhibitory effects on the production of pro-inflammatory cytokines, making it a promising candidate for the development of new anti-inflammatory drugs.
Check Digit Verification of cas no
The CAS Registry Mumber 221044-05-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,1,0,4 and 4 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 221044-05:
(8*2)+(7*2)+(6*1)+(5*0)+(4*4)+(3*4)+(2*0)+(1*5)=69
69 % 10 = 9
So 221044-05-9 is a valid CAS Registry Number.
221044-05-9Relevant articles and documents
Cobalt-catalyzed intramolecular decarbonylative coupling of acylindoles and diarylketones through the cleavage of C-C bonds
Lu, Hong,Wei, Hao,Xu, Wen-Hua,Yu, Tian-Yang
, p. 12336 - 12340 (2020/12/08)
We report here cobalt-N-heterocyclic carbene catalytic systems for the intramolecular decarbonylative coupling through the chelation-assisted C-C bond cleavage of acylindoles and diarylketones. The reaction tolerates a wide range of functional groups such as alkyl, aryl, and heteroaryl groups, giving the decarbonylative products in moderate to excellent yields. This transformation involves the cleavage of two C-C bonds and formation of a new C-C bond without the use of noble metals, thus reinforcing the potential application of decarbonylation as an effective tool for C-C bond formation. This journal is
