(S)-2-amino-1-((R)-2-methyloxiran-2-yl)-3-phenylpropan-1-one trifluoroacetate

Base Information

Chemical Name:(S)-2-amino-1-((R)-2-methyloxiran-2-yl)-3-phenylpropan-1-one trifluoroacetate
CAS No.:1148157-29-2
Molecular Formula:C14H16F3NO4
Molecular Weight:319.281
Hs Code.:
Mol file:1148157-29-2.mol

Synonyms:(S)-2-amino-1-((R)-2-methyloxiran-2-yl)-3-phenylpropan-1-one trifluoroacetate

Suppliers and Price of (S)-2-amino-1-((R)-2-methyloxiran-2-yl)-3-phenylpropan-1-one trifluoroacetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of (S)-2-amino-1-((R)-2-methyloxiran-2-yl)-3-phenylpropan-1-one trifluoroacetate

Chemical Property:

PSA：92.92000
LogP:2.24800

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

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Technology Process of (S)-2-amino-1-((R)-2-methyloxiran-2-yl)-3-phenylpropan-1-one trifluoroacetate

There total 14 articles about (S)-2-amino-1-((R)-2-methyloxiran-2-yl)-3-phenylpropan-1-one trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1010136-50-1,1416709-77-7
tert-butyl [(1S)-1-[(2R)-2-methyloxiran-2-yl]-1-oxo-3-phenylpropan-2-yl]carbamate

: 76-05-1
trifluoroacetic acid

: 1148157-29-2
(S)-2-amino-1-((R)-2-methyloxiran-2-yl)-3-phenylpropan-1-one trifluoroacetate

Guidance literature:: In dichloromethane; at 0 ℃; for 0.5h;

Reference yield:

: 935888-15-6
benzyl (S)-1-((R)-2-methyloxiran-2-yl)-1-oxo-3-phenylpropan-2-ylcarbamate

: 76-05-1
trifluoroacetic acid

: 1148157-29-2
(S)-2-amino-1-((R)-2-methyloxiran-2-yl)-3-phenylpropan-1-one trifluoroacetate

Guidance literature:: With 10% palladium on carbon; hydrogen; at 0 ℃; for 2h;
DOI:10.1021/jm801329v

Reference yield:

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 1148157-29-2
(S)-2-amino-1-((R)-2-methyloxiran-2-yl)-3-phenylpropan-1-one trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / dichloromethane / 0.33 h / 0 °C

1.2: 1.25 h

2.1: tetrahydrofuran / 2.67 h / 0 - 20 °C

3.1: dihydrogen peroxide; N-ethyl-N,N-diisopropylamine / methanol; water; benzonitrile / 0 - 20 °C

4.1: dichloromethane / 0.5 h / 0 °C

With 4-methyl-morpholine; dihydrogen peroxide; N-ethyl-N,N-diisopropylamine; isobutyl chloroformate; In tetrahydrofuran; methanol; dichloromethane; water; benzonitrile;