triethyl 2-methylpropane-1,1,3-tricarboxylate

Base Information

• Chemical Name: triethyl 2-methylpropane-1,1,3-tricarboxylate
• CAS No.: 2907-92-8
• Molecular Formula: C13H22 O6
• Molecular Weight: 274.314
• Mol file: 2907-92-8.mol

Synonyms:1,1,3-Propanetricarboxylicacid, 2-methyl-, triethyl ester (6CI,7CI,8CI,9CI); NSC 403873

Chemical Property of triethyl 2-methylpropane-1,1,3-tricarboxylate

Chemical Property:

• Vapor Pressure: 0.000716mmHg at 25°C
• Boiling Point: 307.6°Cat760mmHg
• Flash Point: 128.6°C
• Density: 1.078g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of triethyl 2-methylpropane-1,1,3-tricarboxylate

There total 9 articles about triethyl 2-methylpropane-1,1,3-tricarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

ethyl (E)-crotonate (623-70-1) + diethyl malonate (105-53-3) → 2-methyl-propane-1,1,3-tricarboxylic acid triethyl ester (2907-92-8)

Guidance literature:

With sodium t-butanolate; (R)-1,1'-binaphthalene-2,2'-diol lithium salt; In tetrahydrofuran; at 20 - 25 ℃; for 72h;

DOI:10.1023/A:1013131621384

Reference yield:

ethyl crotonate (10544-63-5) + diethyl malonate (105-53-3) → 2-methyl-propane-1,1,3-tricarboxylic acid triethyl ester (2907-92-8)

Guidance literature:

diethyl malonate; With sodium methylate; In tetrahydrofuran; methanol; at 23 ℃; for 0.166667h;

ethyl crotonate; In tetrahydrofuran; methanol; at 45 - 50 ℃; for 4.16667h;

DOI:10.1021/op500271w

Reference yield:

sodium diethylmalonate (996-82-7) → 2-methyl-propane-1,1,3-tricarboxylic acid triethyl ester (2907-92-8)

Guidance literature:

With benzene;

upstream raw materials:

sodium diethylmalonate

ethyl crotonate

crotonic acid methyl ester

sodium diethylmalonate

Downstream raw materials:

3-methyl glutaric acid

cis-jasmone

dihydro-cis-jasmone

Refernces

• 1、 Daviaud,G. et al.. "-". . p. 5169 - 5170. Retrieved 1970.
• 2、 Lane, Jonathan W.,Spencer, Keith L.,Shakya, Sagar R.,Kallan, Nicholas C.,Stengel, Peter J.,Remarchuk, Travis. "Synthesis of Akt inhibitor ipatasertib. part 1. Route scouting and early process development of a challenging cyclopentylpyrimidine intermediate". . p. 1641 - 1651. Retrieved 2015/02/02.