(1H-Pyrrolo[2,3-b]pyridin-6-yl)methanol

Base Information

• Chemical Name: (1H-Pyrrolo[2,3-b]pyridin-6-yl)methanol
• CAS No.: 1263413-97-3
• Molecular Formula: C₈H₈N₂O
• Molecular Weight: 148.164
• Hs Code.: 2933990090
• Mol file: 1263413-97-3.mol

Synonyms:(1H-Pyrrolo[2,3-b]pyridin-6-yl)methanol

Chemical Property of (1H-Pyrrolo[2,3-b]pyridin-6-yl)methanol

Chemical Property:

• PKA: 13.68±0.10(Predicted)
• PSA: 48.91000
• Density: 1.360±0.06 g/cm3(Predicted)
• LogP: 1.05520

Purity/Quality:

98%min ^*data from raw suppliers

(1H-Pyrrolo[2,3-b]pyridin-6-yl)methanol Aldrich ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1H-Pyrrolo[2,3-b]pyridin-6-yl)methanol

There total 2 articles about (1H-Pyrrolo[2,3-b]pyridin-6-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1H-pyrrolo[2,3-b]pyridine-6-carboxylic acid methyl ester (1256825-86-1) → 1H-pyrrolo[2,3-b]pyridin-6-ylmethanol (1263413-97-3)

Guidance literature:

1H-pyrrolo[2,3-b]pyridine-6-carboxylic acid methyl ester; With lithium borohydride; In methanol; at 20 - 50 ℃; for 183h;

With hydrogenchloride; water;

Reference yield:

1H-pyrrolo[2,3-b]pyridine-6-carboxylic acid (898746-35-5) → 1H-pyrrolo[2,3-b]pyridin-6-ylmethanol (1263413-97-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / 18 h / Reflux

2: lithium borohydride / methanol / 183 h / 20 - 50 °C

With lithium borohydride; sulfuric acid; In methanol;

upstream raw materials:

1H-pyrrolo[2,3-b]pyridine-6-carboxylic acid methyl ester

1H-pyrrolo[2,3-b]pyridine-6-carboxylic acid

Refernces