AMG 232

Base Information

Chemical Name:AMG 232
CAS No.:1352066-68-2
Molecular Formula:C28H35Cl2NO5S
Molecular Weight:568.562
Hs Code.:
Mol file:1352066-68-2.mol

Synonyms:AMG 232;2-((3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

Suppliers and Price of AMG 232

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
AMG-232
10mg
$ 415.00

DC Chemicals
AMG232 >98%
100 mg
$ 650.00

DC Chemicals
AMG232 >98%
250 mg
$ 1200.00

DC Chemicals
AMG232 >98%
1 g
$ 2500.00

Crysdot
AMG232 98+%
100mg
$ 1570.00

Crysdot
AMG232 98+%
10mg
$ 380.00

Crysdot
AMG232 98+%
50mg
$ 945.00

ChemScene
AMG232 99.90%
50mg
$ 780.00

ChemScene
AMG232 99.90%
100mg
$ 1200.00

ChemScene
AMG232 99.90%
10mg
$ 228.00

Total 16 raw suppliers

Chemical Property of AMG 232

Chemical Property:

Boiling Point:732.7±60.0 °C(Predicted)
PKA:4.29±0.10(Predicted)
PSA：100.13000
Density:1.254±0.06 g/cm3(Predicted)
LogP:7.39810
Storage Temp.:-20°C Freezer
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

AMG-232 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses AMG-232 is a potent MDM2-P53 inhibitor for use as an anti-tumor agent.

Technology Process of AMG 232

There total 28 articles about AMG 232 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: (3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methylpiperidin-2-one

: 1352066-68-2
2-((3R,5R,6S)-5-(3-chlorophenyl)-6- (4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

Guidance literature:: With ruthenium trichloride; sodium periodate; In water; ethyl acetate; acetonitrile;
DOI:10.1021/jm500627s

Reference yield:

: (3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylmercapto)-3-methylbutan-2-yl)-3-methylpiperidin-2-one

: 1352066-68-2
2-((3R,5R,6S)-5-(3-chlorophenyl)-6- (4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

Guidance literature:: With sodium periodate; ruthenium(III) trichloride hydrate; In tetrachloromethane; water; acetonitrile; for 36h; Inert atmosphere;
DOI:10.1021/jm401753e

Reference yield:

: 1352073-07-4
(3S,5R,6S)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-hydroxy-3-methylbutan-2-yl)-3-methylpiperidin-2-one

: 1352066-68-2
2-((3R,5R,6S)-5-(3-chlorophenyl)-6- (4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 24 h / 25 - 90 °C

2: sodium periodate; ruthenium(III) trichloride hydrate / water; tetrachloromethane; acetonitrile / 36 h / Inert atmosphere

With sodium periodate; ruthenium(III) trichloride hydrate; In tetrachloromethane; water; acetonitrile;
DOI:10.1021/jm401753e