(3S,5R,6R)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one

Base Information

Chemical Name:(3S,5R,6R)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one
CAS No.:1352076-45-9
Molecular Formula:C₂₁H₂₀Cl₂O₂
Molecular Weight:375.295
Hs Code.:

Synonyms:(3S,5R,6R)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one

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Chemical Property of (3S,5R,6R)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one

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Technology Process of (3S,5R,6R)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one

There total 19 articles about (3S,5R,6R)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.2%

: (±)-(3S,5R,6R)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one

: 1352076-45-9
(3S,5R,6R)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one

: (3R,5R,6R)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one

Guidance literature:: With Phenomenex Lux-2; In methanol; carbon dioxide; at 40 ℃; for 0.0833333h; under 75007.5 Torr; Supercritical conditions; Resolution of racemate; liquid CO₂;

Reference yield: 94.0%

: (5R,6R)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one

: 106-95-6
allyl bromide

: 1352076-45-9
(3S,5R,6R)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -30 - -5 ℃; stereoselective reaction;
DOI:10.1021/jm500627s

Reference yield: 63.0%

: isopropyl 4-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-5-oxopentanoate

: 106-95-6
allyl bromide

: 1352076-45-9
(3S,5R,6R)-3-allyl-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyltetrahydro-2H-pyran-2-one

Guidance literature:: isopropyl 4-(3-chlorophenyl)-5-(4-chlorophenyl)-2-methyl-5-oxopentanoate; With potassium tert-butylate; hydrogen; RuCl(S-xylbinap)(S-DAIPEN); In isopropyl alcohol; at 20 ℃; for 5.5h; under 3750.38 Torr; Large scale;

With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 24h; Large scale;

allyl bromide; Further stages; Large scale;