2-BroMo-3-Methoxybenzonitrile

Base Information

• Chemical Name: 2-BroMo-3-Methoxybenzonitrile
• CAS No.: 1261816-95-8
• Molecular Formula: C8H6BrNO
• Molecular Weight: 212.046
• Hs Code.: 2926907090
• Mol file: 1261816-95-8.mol

Synonyms:2-BroMo-3-Methoxybenzonitrile

Chemical Property of 2-BroMo-3-Methoxybenzonitrile

Chemical Property:

• Boiling Point: 285.9±30.0 °C(Predicted)
• PSA: 33.02000
• Density: 1.56±0.1 g/cm3(Predicted)
• LogP: 2.32938
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98% ^*data from raw suppliers

2-bromo-3-methoxybenzonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BroMo-3-Methoxybenzonitrile

There total 1 articles about 2-BroMo-3-Methoxybenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

sodium methylate (124-41-4) + 2-bromo-3-fluorobenzonitrile (425379-16-4) → 2-bromo-3-methoxybenzonitrile (1261816-95-8)

Guidance literature:

In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1021/jm2015952

Reference yield: 88.0%

2-bromo-3-methoxybenzonitrile (1261816-95-8) → C8H5BrINO

Guidance literature:

With N-iodo-succinimide; palladium diacetate; toluene-4-sulfonic acid; In 1,2-dichloro-ethane; at 70 ℃; for 12h; Inert atmosphere;

Reference yield: 47.0%

2-bromo-3-methoxybenzonitrile (1261816-95-8) + β-D-glucose pentaacetate (604-69-3) → (3aS,5R,6R,7S,7aR)-5-(acetoxymethyl)-2-(2-bromo-3-methoxyphenyl)-3a,6,7,7a-tetrahydro-5H-pyrano[2,3-d]oxazole-6,7-diyl diacetate + 5-(acetoxymethyl)-2-(2-bromo-3-methoxyphenyl)-3a,6,7,7a-tetrahydro-5H-pyrano[2,3-d]oxazole-6,7-diyl diacetate

Guidance literature:

With trifluorormethanesulfonic acid; In dichloromethane; water; at 20 ℃; for 2h; stereoselective reaction;

DOI:10.1039/d0ob02477e

upstream raw materials:

sodium methylate

2-bromo-3-fluorobenzonitrile

Refernces