Spiro[piperidine-4,7'-[7H]thieno[2,3-c]pyran], 4',5'-dihydro-

Base Information

• Chemical Name: Spiro[piperidine-4,7'-[7H]thieno[2,3-c]pyran], 4',5'-dihydro-
• CAS No.: 1283095-47-5
• Molecular Formula: C11H15NOS
• Molecular Weight: 209.312
• Hs Code.: 2934999090
• Mol file: 1283095-47-5.mol

Synonyms:Spiro[piperidine-4,7'-[7H]thieno[2,3-c]pyran], 4',5'-dihydro-;4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]

Chemical Property of Spiro[piperidine-4,7'-[7H]thieno[2,3-c]pyran], 4',5'-dihydro-

Chemical Property:

• PSA: 49.50000
• LogP: 2.22830

Purity/Quality:

97% ^*data from raw suppliers

4'',5''-dihydrospiro[piperidine-4,7''-thieno[2,3-c]pyran] ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Spiro[piperidine-4,7'-[7H]thieno[2,3-c]pyran], 4',5'-dihydro-

There total 7 articles about Spiro[piperidine-4,7'-[7H]thieno[2,3-c]pyran], 4',5'-dihydro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-(2-hydroxyethyl)thiophene (13781-67-4) + N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → 4′,5′-dihydrospiro[piperidine-4,7′-thieno[2,3-c]pyran] (1283095-47-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 20.5h;

DOI:10.1021/jm101487v

Reference yield: 86.0%

4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-ium trifluoroacetate (1307248-40-3) → 4′,5′-dihydrospiro[piperidine-4,7′-thieno[2,3-c]pyran] (1283095-47-5)

Guidance literature:

With water; sodium hydroxide; In dichloromethane; Cooling with ice;

Reference yield: 53.0%

3-(2-hydroxyethyl)thiophene (13781-67-4) + 4-piperidone hydrochloride (41979-39-9) → 4′,5′-dihydrospiro[piperidine-4,7′-thieno[2,3-c]pyran] (1283095-47-5)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at -5 - 25 ℃; for 37h; Industrial scale;

DOI:10.1021/op5000094

upstream raw materials:

4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran]-1-ium trifluoroacetate

3-(2-hydroxyethyl)thiophene

N-tert-butyloxycarbonylpiperidin-4-one

4-piperidone hydrochloride

Downstream raw materials:

tert-butyl-4′,5′-dihydro-1H-spiro[piperidine-4,7′-thieno[2,3-c]pyran]-1-carboxylate

2'-chloro-4',5'-dihydrospiro[piperidine-4,7'-thieno[2,3-c]pyran] hydrochloride

[2-[4-[(2-chloro-4,4-difluoro-spiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)methyl]-3-methyl-pyrazol-1-yl]-3-pyridyl]methanol

tert-butyl 2′-chloro-4′,5′-dihydrospiro-[piperidine-4,7′-thieno[2,3-c]pyran]-1-carboxylate