Ethyl 6-ethoxy-4-hydroxyquinoline-3-carboxylate

Base Information

• Chemical Name: Ethyl 6-ethoxy-4-hydroxyquinoline-3-carboxylate
• CAS No.: 303121-08-6
• Molecular Formula: C₁₄H₁₅NO₄
• Molecular Weight: 261.277
• Hs Code.: 2933499090
• DSSTox Substance ID: DTXSID50352223
• Wikidata: Q82129249
• Mol file: 303121-08-6.mol

Synonyms:ethyl 6-ethoxy-4-hydroxyquinoline-3-carboxylate;303121-08-6;ethyl 6-ethoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate;6-Ethoxy-4-hydroxyquinoline-3-carboxylic acid ethyl ester;127285-44-3;6165-50-0;ethyl 6-ethoxy-4-oxo-1H-quinoline-3-carboxylate;AURORA 17941;6-Ethoxy-4-hydroxy-quinoline-3-carboxylic acid ethyl ester;CBMicro_007187;Oprea1_633537;Oprea1_815392;SCHEMBL618410;DTXSID50352223;BDMLESWGGIPUTO-UHFFFAOYSA-N;HMS1611M15;SMSF0016046;CCG-17785;MFCD01610200;STK942310;AKOS000669640;AKOS002250089;AB09299;CB09574;SB69973;CS-16312;BIM-0007259.P001;CS-0095263;FT-0714666;ethyl6-ethoxy-4-hydroxyquinoline-3-carboxylate;N16919;SR-01000453227;SR-01000453227-1;3-Quinolinecarboxylic acid, 6-ethoxy-4-hydroxy-, ethyl ester

Chemical Property of Ethyl 6-ethoxy-4-hydroxyquinoline-3-carboxylate

Chemical Property:

• Vapor Pressure: 8.43E-07mmHg at 25°C
• Melting Point: 261-262 °C(Solv: ethanol (64-17-5))
• Boiling Point: 406°C at 760 mmHg
• PKA: 2.75±0.50(Predicted)
• Flash Point: 199.3°C
• PSA: 68.65000
• Density: 1.216g/cm³
• LogP: 2.51580
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 261.10010796
• Heavy Atom Count: 19
• Complexity: 391

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl6-ethoxy-4-hydroxyquinoline-3-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC2=C(C=C1)NC=C(C2=O)C(=O)OCC

Technology Process of Ethyl 6-ethoxy-4-hydroxyquinoline-3-carboxylate

There total 8 articles about Ethyl 6-ethoxy-4-hydroxyquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

→ ethyl 6-ethoxy-4-hydroxyquinoline-3-carboxylate (127285-44-3,303121-08-6)

Guidance literature:

at 120 ℃; for 4h; Inert atmosphere;

In diphenylether; at 260 ℃; for 8h; Inert atmosphere;

Reference yield:

4-Ethoxyaniline (156-43-4) + diethyl 2-ethoxymethylenemalonate (87-13-8) → ethyl 6-ethoxy-4-hydroxyquinoline-3-carboxylate (127285-44-3,303121-08-6)

Guidance literature:

Reference yield:

2-(4-ethoxy-anilinomethylene)-propanedioic acid diethyl ester (103976-28-9) → 6-ethoxy-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester (127285-44-3,303121-08-6)

Guidance literature:

In various solvent(s); for 1h; Heating;

DOI:10.1021/jm050048t

upstream raw materials:

2-(4-ethoxy-anilinomethylene)-propanedioic acid diethyl ester

4-Ethoxyaniline

diethyl 2-ethoxymethylenemalonate

Downstream raw materials:

ethyl 4-amino-6-ethoxyquinoline-3-carboxylate

4-amino-6-ethoxyquinoline-3-carboxylic acid

ethyl 4-chloro-6-ethoxyquinoline-3-carboxylate

6-ethoxy-4-hydroxy-quinoline-3-carboxylic acid