2-tert-butoxy-5-fluoroanilinedn

Base Information

• Chemical Name: 2-tert-butoxy-5-fluoroanilinedn
• CAS No.: 862594-16-9
• Molecular Formula: C10H14FNO
• Molecular Weight: 183.226
• Hs Code.: 2922290090
• Mol file: 862594-16-9.mol

Synonyms:2-tert-butoxy-5-fluoroanilinedn;Benzenamine, 2-(1,1-dimethylethoxy)-5-fluoro-

Chemical Property of 2-tert-butoxy-5-fluoroanilinedn

Chemical Property:

• PSA: 35.25000
• LogP: 3.16640

Purity/Quality:

99% ^*data from raw suppliers

2-(tert-Butoxy)-5-fluoroaniline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-tert-butoxy-5-fluoroanilinedn

There total 3 articles about 2-tert-butoxy-5-fluoroanilinedn which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-tert-butoxy-4-fluoro-2-nitrobenzene (142596-59-6) → 2-tert-butoxy-5-fluoroaniline (862594-16-9)

Guidance literature:

With hydrogen; platinum(IV) oxide; In methanol; at 20 ℃; for 18h; under 760 Torr;

DOI:10.1021/ol0518840

Reference yield:

1,4-difluoro-2-nitrobenzene (364-74-9) → 2-tert-butoxy-5-fluoroaniline (862594-16-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / tetrahydrofuran / 0 - 20 °C

2: 96 percent / H₂ / PtO₂ / methanol / 18 h / 20 °C / 760 Torr

With hydrogen; platinum(IV) oxide; In tetrahydrofuran; methanol;

DOI:10.1021/ol0518840

Reference yield:

→ 2-tert-butoxy-5-fluoroaniline (862594-16-9)

Guidance literature:

upstream raw materials:

1-tert-butoxy-4-fluoro-2-nitrobenzene

1,4-difluoro-2-nitrobenzene

Downstream raw materials:

2-(benzyl-{2-[4-(4-phenyl-butoxy)-phenyl]-ethyl}-amino)-1-(4-tert-butoxy-2-isopropoxy-benzothiazol-7-yl)-ethanone

7-[(benzyl-{2-[4-(4-phenyl-butoxy)-phenyl]-ethyl}-amino)-acetyl]-4-hydroxy-3H-benzothiazol-2-one

7-[(R)-2-((1S,2S)-2-benzyloxy-cyclopentylamino)-1-hydroxy-ethyl]-4-hydroxy-3H-benzothiazol-2-one

4-hydroxy-7-{(R)-1-hydroxy-2-[2-(4-propyl-phenyl)-ethylamino]-ethyl}-3H-benzothiazol-2-one hydrochloride

Refernces

• 1、 Fairhurst, Robin A.,Janus, Diana,Lawrence, Annabel. "Synthesis of the marine sponge derived β2-adrenoceptor agonist S1319". . p. 4697 - 4700. Retrieved 2007/10/03.
• 2、 -. "BENZOTHIAZOLE DERIVATIVES HAVING BETA-2-ADRENORECEPTOR AGONIST ACTIVITY". Page 22. . Retrieved 2008/06/13.