SR9009

Base Information

Chemical Name:SR9009
CAS No.:1379686-30-2
Molecular Formula:C20H24ClN3O4S
Molecular Weight:437.947
Hs Code.:
Mol file:1379686-30-2.mol

Synonyms:SR9009;3-[[[(4-Chlorophenyl)methyl][(5-nitro-2-thienyl)methyl]amino]methyl]-1-pyrrolidinecarboxylic acid ethyl ester

Suppliers and Price of SR9009

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
SR9009
5mg
$ 70.00

TRC
SR9009
25mg
$ 165.00

Tocris
SR9009 ≥98%(HPLC)
50
$ 696.00

Tocris
SR9009 ≥98%(HPLC)
10
$ 169.00

DC Chemicals
Stenabolic(SR9009) >98%
100 mg
$ 200.00

DC Chemicals
Stenabolic(SR9009) >98%
1 g
$ 800.00

Crysdot
SR9009 98+%
50mg
$ 321.00

Crysdot
SR9009 98+%
100mg
$ 529.00

Chemenu
ethyl3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)pyrrolidine-1-carboxylate 98%
100mg
$ 503.00

Cayman Chemical
SR9009 ≥98%
10mg
$ 125.00

Total 115 raw suppliers

Chemical Property of SR9009

Chemical Property:

Boiling Point:547.2±45.0 °C(Predicted)
PKA:6.12±0.50(Predicted)
PSA：106.84000
Density:1.327±0.06 g/cm3(Predicted)
LogP:5.25140
Storage Temp.:-20°
Solubility.:Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (up to 20 mg/ml).

Purity/Quality:

99%, ^*data from raw suppliers

SR9009 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description SR-9009 is an agonist at nuclear receptor Rev-ErbA. Greatly diminishes VILI-induced lung edema, inflammatory cell infiltration and TNFα production in a rat lung injury model. SR-9009 suppresses atherosclerosis in a mouse model. Specifically lethal to cancer cells and oncogene-induced senescent cells with no effect on the viability of normal cells or tissues. Disrupts pain associated with osteoarthritis by reducing BMAL1 expression in bmal1f/fNav1.8CreERT mice.
Uses SR 9009 is a synthetic REV-ERB agonist that regulates circadian behavior and metabolism; has potential use in the treatment of sleep disorders and metabolic diseases. It is a lead compound for a new class of cancer drugs associated with the body’s circadian clock.

Technology Process of SR9009

There total 5 articles about SR9009 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4521-33-9
5-nitro-2-thiophenecarboxaldehyde

: 1379686-30-2
SR₉₀₀₉

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane

2: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane

3: trifluoroacetic acid / dichloromethane

4: triethylamine / dichloromethane

With sodium tris(acetoxy)borohydride; acetic acid; triethylamine; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2012.04.126

Reference yield:

: 1384516-10-2
N-(4-chlorobenzyl)-1-(5-nitrothiophen-2-yl)methanamine

: 1379686-30-2
SR₉₀₀₉

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tris(acetoxy)borohydride; acetic acid / 1,2-dichloro-ethane

2: trifluoroacetic acid / dichloromethane

3: triethylamine / dichloromethane

With sodium tris(acetoxy)borohydride; acetic acid; triethylamine; trifluoroacetic acid; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1016/j.bmcl.2012.04.126

Reference yield:

: 1384516-20-4
tert-butyl 3-(((4-chlorobenzyl)((5-nitrothiophen-2-yl)methyl)amino)methyl)pyrrolidine-1-carboxylate

: 1379686-30-2
SR₉₀₀₉

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane

2: triethylamine / dichloromethane

With triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmcl.2012.04.126