Methyl 3-(4-fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate

Base Information

Chemical Name:Methyl 3-(4-fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate
CAS No.:917889-25-9
Molecular Formula:C16H11FN2O4
Molecular Weight:314.273
Hs Code.:
DSSTox Substance ID:DTXSID30701578
Wikidata:Q82633298
Mol file:917889-25-9.mol

Synonyms:METHYL 3-(4-FLUOROPHENYL)-2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE-7-CARBOXYLATE;SCHEMBL4253105;DTXSID30701578;917889-25-9;EN300-18144287

Suppliers and Price of Methyl 3-(4-fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Methyl 3-(4-fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate

Chemical Property:

PSA：81.42000
LogP:2.01700
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:314.07028500
Heavy Atom Count:23
Complexity:504

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=CC2=C(C=C1)C(=O)N(C(=O)N2)C3=CC=C(C=C3)F

Technology Process of Methyl 3-(4-fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate

There total 1 articles about Methyl 3-(4-fluorophenyl)-2,4-dioxo-1,2,3,4-tetrahydroquinazoline-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 5372-81-6
dimethyl aminoterephthalate

: 1195-45-5
para-fluorophenyl isocyanate

: 917889-25-9
3-(4-fluoro-phenyl)-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-7-carboxylic acid methyl ester

Guidance literature:: With triethylamine; In 1,4-dioxane; at 90 ℃; for 72h;

Reference yield: 98.0%

: 917889-25-9
3-(4-fluoro-phenyl)-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-7-carboxylic acid methyl ester

: 3-(4-fluoro-phenyl)-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-7-carboxylic acid

Guidance literature:: 3-(4-fluoro-phenyl)-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-7-carboxylic acid methyl ester; With sodium hydroxide; water; In 1,4-dioxane; at 20 ℃; for 1h;

With hydrogenchloride; water; In 1,4-dioxane;