methyl 2-chloro-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate.

Base Information

Chemical Name:methyl 2-chloro-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate.
CAS No.:1373278-09-1
Molecular Formula:C₁₆H₁₀ClFN₂O₃
Molecular Weight:332.718
Hs Code.:

Synonyms:methyl 2-chloro-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate.

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Chemical Property of methyl 2-chloro-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate.

Chemical Property:

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Technology Process of methyl 2-chloro-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate.

There total 3 articles about methyl 2-chloro-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate. which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 917889-25-9
3-(4-fluoro-phenyl)-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-7-carboxylic acid methyl ester

: 1373278-09-1
methyl 2-chloro-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate.

Guidance literature:: With N,N-dimethyl-aniline; trichlorophosphate; at 110 ℃; for 36h; Inert atmosphere;

Reference yield:

: 1195-45-5
para-fluorophenyl isocyanate

: 1373278-09-1
methyl 2-chloro-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate.

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 1,4-dioxane / 16 h / 80 °C

2: trichlorophosphate; N,N-dimethyl-aniline / 36 h / 110 °C / Inert atmosphere

With N,N-dimethyl-aniline; triethylamine; trichlorophosphate; In 1,4-dioxane;

Reference yield:

: 5372-81-6
dimethyl aminoterephthalate

: 1373278-09-1
methyl 2-chloro-3-(4-fluorophenyl)-4-oxo-3,4-dihydroquinazoline-7-carboxylate.

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / 1,4-dioxane / 16 h / 80 °C

2: trichlorophosphate; N,N-dimethyl-aniline / 36 h / 110 °C / Inert atmosphere

With N,N-dimethyl-aniline; triethylamine; trichlorophosphate; In 1,4-dioxane;