Benzo[b]thiophene-2-carboxylic acid, 3-chloro-5-Methoxy-6-Methyl-, 1-Methylethyl ester, 1-oxide

Base Information

Chemical Name:Benzo[b]thiophene-2-carboxylic acid, 3-chloro-5-Methoxy-6-Methyl-, 1-Methylethyl ester, 1-oxide
CAS No.:809281-52-5
Molecular Formula:C₁₄H₁₅ClO₄S
Molecular Weight:314.79
Hs Code.:
Mol file:809281-52-5.mol

Synonyms:Benzo[b]thiophene-2-carboxylic acid, 3-chloro-5-Methoxy-6-Methyl-, 1-Methylethyl ester, 1-oxide

Suppliers and Price of Benzo[b]thiophene-2-carboxylic acid, 3-chloro-5-Methoxy-6-Methyl-, 1-Methylethyl ester, 1-oxide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

American Custom Chemicals Corporation
ISOPROPYL-3-CHLORO-5-METHOXY-6-METHYLBENZO[B]THIOPHENE-2-CARBOXYLATE 1-OXIDE 95.00%
5MG
$ 504.00

Total 4 raw suppliers

Chemical Property of Benzo[b]thiophene-2-carboxylic acid, 3-chloro-5-Methoxy-6-Methyl-, 1-Methylethyl ester, 1-oxide

Chemical Property:

PSA：74.30000
LogP:4.31810

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

ISOPROPYL-3-CHLORO-5-METHOXY-6-METHYLBENZO[B]THIOPHENE-2-CARBOXYLATE 1-OXIDE 95.00% ^*data from reagent suppliers

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Technology Process of Benzo[b]thiophene-2-carboxylic acid, 3-chloro-5-Methoxy-6-Methyl-, 1-Methylethyl ester, 1-oxide

There total 4 articles about Benzo[b]thiophene-2-carboxylic acid, 3-chloro-5-Methoxy-6-Methyl-, 1-Methylethyl ester, 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 1056047-21-2
3-chloro-5-methoxy-6-methyl-benzo[b]thiophene-2-carboxylic acid isopropyl ester

: 809281-52-5
3-chloro-5-methoxy-6-methyl-1-oxo-benzo[b]thiophene-2-carboxylic acid isopropyl ester

Guidance literature:: With dihydrogen peroxide; In dichloromethane; water; trifluoroacetic acid; at 0 - 20 ℃; for 2.25h;

Reference yield:

: 802908-64-1
3-chloro-5-methoxy-6-methyl-benzo[b]thiophene-2-carbonyl chloride

: 809281-52-5
3-chloro-5-methoxy-6-methyl-1-oxo-benzo[b]thiophene-2-carboxylic acid isopropyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; triethylamine / 1 h / 80 °C

2: dihydrogen peroxide / dichloromethane; water; trifluoroacetic acid / 2.25 h / 0 - 20 °C

With dmap; dihydrogen peroxide; triethylamine; In dichloromethane; water; trifluoroacetic acid;

Reference yield:

: 24973-22-6
3-methoxy-4-methylbenzaldehyde

: 809281-52-5
3-chloro-5-methoxy-6-methyl-1-oxo-benzo[b]thiophene-2-carboxylic acid isopropyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: piperidine; pyridine / 2.5 h / Heating / reflux

2: pyridine; thionyl chloride / DMF (N,N-dimethyl-formamide); chlorobenzene / 18 h / Heating / reflux

3: dmap; triethylamine / 1 h / 80 °C

4: dihydrogen peroxide / dichloromethane; water; trifluoroacetic acid / 2.25 h / 0 - 20 °C

With piperidine; pyridine; dmap; thionyl chloride; dihydrogen peroxide; triethylamine; In DMF (N,N-dimethyl-formamide); dichloromethane; water; chlorobenzene; trifluoroacetic acid;