methyl 3-chloro-2-(4-fluorophenyl)quinoxaline-6-carboxylate

Base Information

Chemical Name:methyl 3-chloro-2-(4-fluorophenyl)quinoxaline-6-carboxylate
CAS No.:1268867-03-3
Molecular Formula:C₁₆H₁₀ClFN₂O₂
Molecular Weight:316.719
Hs Code.:
Mol file:1268867-03-3.mol

Synonyms:methyl 3-chloro-2-(4-fluorophenyl)quinoxaline-6-carboxylate

Suppliers and Price of methyl 3-chloro-2-(4-fluorophenyl)quinoxaline-6-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 2 raw suppliers

Chemical Property of methyl 3-chloro-2-(4-fluorophenyl)quinoxaline-6-carboxylate

Chemical Property:

Purity/Quality:: 99% ，98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of methyl 3-chloro-2-(4-fluorophenyl)quinoxaline-6-carboxylate

There total 7 articles about methyl 3-chloro-2-(4-fluorophenyl)quinoxaline-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.7%

: methyl 2-(4-fluorophenyl)-3-oxo-3,4-dihydroquinoxaline-6-carboxylate

: 1268867-03-3
methyl 3-chloro-2-(4-fluorophenyl)quinoxaline-6-carboxylate

Guidance literature:: With thionyl chloride; In N,N-dimethyl-formamide; at 80 ℃; for 2h;

Reference yield: 40.0%

: 1268867-01-1
methyl 2-(4-fluorophenyl)-3-oxo-1,2,3,4-tetrahydroquinoxaline-6-carboxylate

: 1268867-03-3
methyl 3-chloro-2-(4-fluorophenyl)quinoxaline-6-carboxylate

Guidance literature:: methyl 2-(4-fluorophenyl)-3-oxo-1,2,3,4-tetrahydroquinoxaline-6-carboxylate; With N,N-dimethyl-aniline; trichlorophosphate; at 100 ℃; Neat (no solvent);

With sodium hydrogencarbonate; In water; pH=7;

Reference yield:

: 329-59-9
4-fluoro-3-nitro-benzoic acid methyl ester

: 1268867-03-3
methyl 3-chloro-2-(4-fluorophenyl)quinoxaline-6-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 35 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 30 °C

3.1: trichlorophosphate; N,N-dimethyl-aniline / 100 °C / Neat (no solvent)

3.2: pH 7

With hydrogen; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; trichlorophosphate; palladium 10% on activated carbon; In methanol; N,N-dimethyl-formamide;