methyl 2-(4-fluorophenyl)-3-(3-(methoxymethyl)piperidin-1-yl)quinoxaline-6-carboxylate

Base Information

Chemical Name:methyl 2-(4-fluorophenyl)-3-(3-(methoxymethyl)piperidin-1-yl)quinoxaline-6-carboxylate
CAS No.:1268867-14-6
Molecular Formula:C₂₃H₂₄FN₃O₃
Molecular Weight:409.46
Hs Code.:

Synonyms:methyl 2-(4-fluorophenyl)-3-(3-(methoxymethyl)piperidin-1-yl)quinoxaline-6-carboxylate

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Chemical Property of methyl 2-(4-fluorophenyl)-3-(3-(methoxymethyl)piperidin-1-yl)quinoxaline-6-carboxylate

Chemical Property:

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Technology Process of methyl 2-(4-fluorophenyl)-3-(3-(methoxymethyl)piperidin-1-yl)quinoxaline-6-carboxylate

There total 5 articles about methyl 2-(4-fluorophenyl)-3-(3-(methoxymethyl)piperidin-1-yl)quinoxaline-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 688809-97-4
3-[(methyloxy)methyl]piperidine hydrochloride

: 1268867-03-3
methyl 3-chloro-2-(4-fluorophenyl)quinoxaline-6-carboxylate

: 1268867-14-6
methyl 2-(4-fluorophenyl)-3-(3-(methoxymethyl)piperidin-1-yl)quinoxaline-6-carboxylate

Guidance literature:: 3-[(methyloxy)methyl]piperidine hydrochloride; With sodium methylate; In dichloromethane; at 20 ℃; for 3h;

methyl 3-chloro-2-(4-fluorophenyl)quinoxaline-6-carboxylate; In dimethyl sulfoxide; at 100 ℃; Sealed tube;

Reference yield:

: 329-59-9
4-fluoro-3-nitro-benzoic acid methyl ester

: 1268867-14-6
methyl 2-(4-fluorophenyl)-3-(3-(methoxymethyl)piperidin-1-yl)quinoxaline-6-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 35 °C

2.1: hydrogen / palladium 10% on activated carbon / methanol / 30 °C

3.1: trichlorophosphate; N,N-dimethyl-aniline / 100 °C / Neat (no solvent)

3.2: pH 7

4.1: sodium methylate / dichloromethane / 3 h / 20 °C

4.2: 100 °C / Sealed tube

With hydrogen; sodium methylate; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; trichlorophosphate; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 453-71-4
3-nitro-4-fluorobenzoic acid

: 1268867-14-6
methyl 2-(4-fluorophenyl)-3-(3-(methoxymethyl)piperidin-1-yl)quinoxaline-6-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 3 h / 0 °C / Reflux

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 35 °C

3.1: hydrogen / palladium 10% on activated carbon / methanol / 30 °C

4.1: trichlorophosphate; N,N-dimethyl-aniline / 100 °C / Neat (no solvent)

4.2: pH 7

5.1: sodium methylate / dichloromethane / 3 h / 20 °C

5.2: 100 °C / Sealed tube

With thionyl chloride; hydrogen; sodium methylate; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; trichlorophosphate; palladium 10% on activated carbon; In methanol; dichloromethane; N,N-dimethyl-formamide;