ent-EzetiMibe

Base Information

Chemical Name:ent-EzetiMibe
CAS No.:1376614-99-1
Molecular Formula:C24H21F2NO3
Molecular Weight:409.432
Hs Code.:
Mol file:1376614-99-1.mol

Synonyms:ent-EzetiMibe;(3S,4R)-1-(4-Fluorophenyl)-3-[(3R)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-2-azetidinone

Suppliers and Price of ent-EzetiMibe

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
ent-Ezetimibe
5mg
$ 460.00

TRC
ent-Ezetimibe
5mg
$ 180.00

Medical Isotopes, Inc.
ent-Ezetimibe
5 mg
$ 650.00

Alichem
(3S,4R)-1-(4-Fluorophenyl)-3-((R)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one
5g
$ 41406.00

Alichem
(3S,4R)-1-(4-Fluorophenyl)-3-((R)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one
1g
$ 14070.00

Alichem
(3S,4R)-1-(4-Fluorophenyl)-3-((R)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one
250mg
$ 8281.20

Total 15 raw suppliers

Chemical Property of ent-EzetiMibe

Chemical Property:

Boiling Point:654.9±55.0 °C(Predicted)
PKA:9.72±0.30(Predicted)
PSA：60.77000
Density:1.334±0.06 g/cm3(Predicted)
LogP:4.95330
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99%, ^*data from raw suppliers

ent-Ezetimibe ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses An enantiomeric impurity of Ezetimibe (E975005).

Technology Process of ent-EzetiMibe

There total 21 articles about ent-EzetiMibe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.3%

: 1376615-01-8
(3S,4R)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-3-oxopropyl)-4-(4-hydroxyphenyl)azetidin-2-one

: 1376614-99-1,1478664-18-4,1593543-00-0,1593543-07-7,1478664-02-6
(3S,4R)-1-(4-fluorophenyl)-3-((R)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one

Guidance literature:: With dimethylsulfide borane complex; (S)-1-methyl-3,3-diphenyl-hexahydropyrrolo[1,2-c][1,3,2]oxazaborole; In dichloromethane; at 0 ℃;
DOI:10.1016/j.cclet.2014.03.035

Reference yield:

: 1017158-54-1,189028-94-2
C₁₁H₁₃FO₃

: 1478664-18-4,1593543-00-0,1593543-07-7,1478664-02-6
(3S,4R)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one

: 1376614-99-1,1478664-18-4,1593543-00-0,1593543-07-7,1478664-02-6
(3S,4R)-1-(4-fluorophenyl)-3-((R)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one

: 163222-33-1,1478664-18-4,1593543-00-0,1593543-07-7,1478664-02-6
ezetemibe

: 163380-16-3,1478664-18-4,1593543-00-0,1593543-07-7,1478664-02-6
(3R,4S)-1-(4-fluorophenyl)-3-[(3R)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)-azetidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: pyridinium p-toluenesulfonate

2: lithium diisopropyl amide / N,N-dimethyl-formamide

3: palladium on activated charcoal; acetic acid; ammonium acetate / methanol

With palladium on activated charcoal; ammonium acetate; pyridinium p-toluenesulfonate; acetic acid; lithium diisopropyl amide; In methanol; N,N-dimethyl-formamide;
DOI:10.1002/chir.22829