(3S,4R)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-3-oxopropyl)-4-(4-hydroxyphenyl)azetidin-2-one

Base Information

Chemical Name:(3S,4R)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-3-oxopropyl)-4-(4-hydroxyphenyl)azetidin-2-one
CAS No.:1376615-01-8
Molecular Formula:C₂₄H₁₉F₂NO₃
Molecular Weight:407.417
Hs Code.:

Synonyms:(3S,4R)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-3-oxopropyl)-4-(4-hydroxyphenyl)azetidin-2-one

Suppliers and Price of (3S,4R)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-3-oxopropyl)-4-(4-hydroxyphenyl)azetidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(3S,4R)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)-2-azetidinone
10mg
$ 1320.00

Total 4 raw suppliers

Chemical Property of (3S,4R)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-3-oxopropyl)-4-(4-hydroxyphenyl)azetidin-2-one

Chemical Property:

Boiling Point:656.1±55.0 °C(Predicted)
Density:1.325±0.06 g/cm3(Predicted)

Purity/Quality:

98% ^*data from raw suppliers

(3S,4R)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)-2-azetidinone ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses (3S,4R)-1-(4-Fluorophenyl)-3-[3-(4-fluorophenyl)-3-oxopropyl]-4-(4-hydroxyphenyl)-2-azetidinone is a reagent for the preparation of Ezetimibe optical isomers and intermediates.

Technology Process of (3S,4R)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-3-oxopropyl)-4-(4-hydroxyphenyl)azetidin-2-one

There total 16 articles about (3S,4R)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-3-oxopropyl)-4-(4-hydroxyphenyl)azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.9%

: 1593542-76-7
C₃₅H₄₃F₂NO₄Si

: 1376615-01-8
(3S,4R)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-3-oxopropyl)-4-(4-hydroxyphenyl)azetidin-2-one

Guidance literature:: With sulfuric acid; In isopropyl alcohol; at 50 ℃;
DOI:10.1016/j.cclet.2014.03.035

Reference yield: 41.0%

: 1376614-99-1,1478664-18-4,1593543-00-0,1593543-07-7,1478664-02-6
(3S,4R)-1-(4-fluorophenyl)-3-((R)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one

: 1376615-01-8
(3S,4R)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-3-oxopropyl)-4-(4-hydroxyphenyl)azetidin-2-one

Guidance literature:: With manganese(IV) oxide; In dichloromethane; for 42h; Reflux;

Reference yield:

: 3-{4-[2-(4-fluorophenyl)-5,5-dimethyl-[1,3]dioxin-2-yl]butyryl}(4R)-phenyl-1,3-oxazolidin-2-one

: 1376615-01-8
(3S,4R)-1-(4-fluorophenyl)-3-(3-(4-fluorophenyl)-3-oxopropyl)-4-(4-hydroxyphenyl)azetidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: titanium tetrachloride; titanium(IV) isopropylate; N-ethyl-N,N-diisopropylamine / dichloromethane / -40 °C

2: tetrabutyl ammonium fluoride; N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 25 °C

3: sulfuric acid / isopropyl alcohol / 50 °C

With titanium(IV) isopropylate; N,O-bis-(trimethylsilyl)-acetamide; sulfuric acid; tetrabutyl ammonium fluoride; titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; isopropyl alcohol; acetonitrile;
DOI:10.1016/j.cclet.2014.03.035