4-Pyridinecarbonyl chloride, 3,5-difluoro- (9CI)

Base Information

• Chemical Name: 4-Pyridinecarbonyl chloride, 3,5-difluoro- (9CI)
• CAS No.: 383363-42-6
• Molecular Formula: C₆H₂ClF₂NO
• Molecular Weight: 177.538
• Mol file: 383363-42-6.mol

Synonyms:4-Pyridinecarbonyl chloride, 3,5-difluoro- (9CI)

Chemical Property of 4-Pyridinecarbonyl chloride, 3,5-difluoro- (9CI)

Chemical Property:

• PSA: 29.96000
• LogP: 1.73880

Purity/Quality:

3,5-Difluoropyridine-4-carbonylchloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Pyridinecarbonyl chloride, 3,5-difluoro- (9CI)

There total 1 articles about 4-Pyridinecarbonyl chloride, 3,5-difluoro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3,5-difluoro-4-pyridinecarboxylic acid (903522-29-2) → 3,5-difluoroisonicotinoyl chloride (383363-42-6)

Guidance literature:

With oxalyl dichloride; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h;

Reference yield:

3,5-difluoroisonicotinoyl chloride (383363-42-6) + 1-[(2,4-dichlorophenyl)methyl]indazol-3-amine → N-[1-[(2,4-dichlorophenyl)methyl]indazol-3-yl]-3,5-difluoro-pyridine-4-carboxamide

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1016/j.bmcl.2016.12.062

Reference yield:

3,5-difluoroisonicotinoyl chloride (383363-42-6) → C18H23N5O3S

Guidance literature:

Multi-step reaction with 5 steps

1.1: sodium hydroxide / water / 0.5 h / 0 °C

1.2: 1 h / 0 - 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 90 °C

3.1: trichlorophosphate / Reflux

4.1: acetonitrile / 3 h / 20 °C / Reflux

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 4 h / 0 - 90 °C

With sodium hydride; caesium carbonate; sodium hydroxide; trichlorophosphate; In water; N,N-dimethyl-formamide; acetonitrile; mineral oil;

upstream raw materials:

3,5-difluoro-4-pyridinecarboxylic acid

Refernces

• 1、 Bai, Sha,Nagai, Masazumi,Koerner, Steffi K.,Veves, Aristidis,Sun, Lijun. "Structure-activity relationship study and discovery of indazole 3-carboxamides as calcium-release activated calcium channel blockers". . p. 393 - 397. Retrieved 2017/01/17.