903522-29-2 Usage
Uses
Used in Pharmaceutical Industry:
3,5-Difluoropyridine-4-carboxylic acid is used as a key intermediate in the synthesis of pyridyl-fused lactam derivatives, which are important for the development of novel pharmaceutical compounds with potential therapeutic applications.
Used in Chemical Synthesis:
3,5-Difluoropyridine-4-carboxylic acid serves as a versatile building block in organic chemistry, particularly for the preparation of di-substituted isonicotinic acid (I821760). 3,5-Difluoropyridine-4-carboxylic acid can be further utilized in the synthesis of various pyridyl-fused lactam derivatives, expanding the scope of chemical compounds available for research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 903522-29-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,0,3,5,2 and 2 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 903522-29:
(8*9)+(7*0)+(6*3)+(5*5)+(4*2)+(3*2)+(2*2)+(1*9)=142
142 % 10 = 2
So 903522-29-2 is a valid CAS Registry Number.
InChI:InChI=1/C6H3F2NO2/c7-3-1-9-2-4(8)5(3)6(10)11/h1-2H,(H,10,11)
903522-29-2Relevant academic research and scientific papers
The discovery of potent small molecule cyclic urea activators of STING
Banerjee, Monali,Basu, Sourav,Ghosh, Rajib,Middya, Sandip,Pryde, David C.,Shrivastava, Ritesh,Surya, Arjun,Yadav, Dharmendra B.
supporting information, (2022/02/07)
STING mediates innate immune responses that are triggered by the presence of cytosolic DNA. Activation of STING to boost antigen recognition is a therapeutic modality that is currently being tested in cancer patients using nucleic-acid based macrocyclic STING ligands. We describe here the discovery of 3,4-dihydroquinazolin-2(1H)-one based 6,6-bicyclic heterocyclic agonists of human STING that activate all known human variants of STING with high potency.
