(1R,2S)-1-(p-Tolyl)cyclopropane-1,2-dicarboxylic acid

Base Information

Chemical Name:(1R,2S)-1-(p-Tolyl)cyclopropane-1,2-dicarboxylic acid
CAS No.:66504-83-4
Molecular Formula:C12H12O4
Molecular Weight:220.22128
Hs Code.:2917399090
DSSTox Substance ID:DTXSID10507959

Synonyms:66504-83-4;(1R,2S)-1-(p-Tolyl)cyclopropane-1,2-dicarboxylic acid;(1R,2S)-1-(4-Methylphenyl)cyclopropane-1,2-dicarboxylic acid;(1R,2S)-1-P-TOLYL-CYCLOPROPANE-1,2-DICARBOXYLIC ACID;SCHEMBL4586758;DTXSID10507959;AKOS015891413;A917813;(1R,2S)-1-(p-Tolyl)cyclopropane-1,2-dicarboxylicacid;(1R,2S)-1-(4-methylphenyl)-1,2-cyclopropanedicarboxylic acid;(1R,2S)-(+)-1-(4-methylphenyl)-1,2-cyclopropanedicarboxylic acid

Suppliers and Price of (1R,2S)-1-(p-Tolyl)cyclopropane-1,2-dicarboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(1R,2S)-1-(p-Tolyl)cyclopropane-1,2-dicarboxylicacid 95+%
1g
$ 1424.00

Chemenu
(1R,2S)-1-(p-tolyl)cyclopropane-1,2-dicarboxylicacid 95%
1g
$ 1342.00

American Custom Chemicals Corporation
(1R,2S)-1-PARA-TOLYL-CYCLOPROPANE-1,2-DICARBOXYLIC ACID 95.00%
5MG
$ 505.82

Alichem
(1R,2S)-1-(p-Tolyl)cyclopropane-1,2-dicarboxylicacid
1g
$ 1244.16

Total 5 raw suppliers

Chemical Property of (1R,2S)-1-(p-Tolyl)cyclopropane-1,2-dicarboxylic acid

Chemical Property:

PSA：74.60000
LogP:1.42190
Storage Temp.:2-8°C
XLogP3:1.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:220.07355886
Heavy Atom Count:16
Complexity:317

Purity/Quality:

97% ^*data from raw suppliers

(1R,2S)-1-(p-Tolyl)cyclopropane-1,2-dicarboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)C2(CC2C(=O)O)C(=O)O
Isomeric SMILES:CC1=CC=C(C=C1)[C@]2(C[C@@H]2C(=O)O)C(=O)O

Technology Process of (1R,2S)-1-(p-Tolyl)cyclopropane-1,2-dicarboxylic acid

There total 6 articles about (1R,2S)-1-(p-Tolyl)cyclopropane-1,2-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 66504-83-4,66504-85-6,66560-11-0,113111-32-3
(1R,2S)-1-p-Tolyl-cyclopropane-1,2-dicarboxylic acid

: 66504-83-4
(1R,2S)-(+)-1-(4-methylphenyl)-1,2-cyclopropanedicarboxylic acid

Guidance literature:: DOI:10.1021/jm00137a002

Reference yield: 80.0%

: 66504-76-5
(1R,2S)-1-p-Tolyl-cyclopropane-1,2-dicarboxylic acid dimethyl ester

: 66504-83-4,66504-85-6,66560-11-0,113111-32-3
(1R,2S)-1-p-Tolyl-cyclopropane-1,2-dicarboxylic acid

Guidance literature:: With potassium hydroxide; In ethanol; water; for 6h; Heating;
DOI:10.1021/jm00137a002

Reference yield:

: 77053-52-2,66505-09-7
methyl bromo(4-methylphenyl)acetate

: 66504-83-4
(1R,2S)-(+)-1-(4-methylphenyl)-1,2-cyclopropanedicarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / NaOMe / diethyl ether / 24 h / Ambient temperature

2: 80 percent / KOH / ethanol; H₂O / 6 h / Heating

3: 92 percent

With potassium hydroxide; sodium methylate; In diethyl ether; ethanol; water;
DOI:10.1021/jm00137a002