2-Chloro-5-hydroxy-4-MethylpyriMidine

Base Information

• Chemical Name: 2-Chloro-5-hydroxy-4-MethylpyriMidine
• CAS No.: 1245506-62-0
• Molecular Formula: C5H5ClN2O
• Molecular Weight: 144.56
• Mol file: 1245506-62-0.mol

Synonyms:2-Chloro-5-hydroxy-4-MethylpyriMidine;2-Chloro-4-methylpyrimidin-5-ol;2-chloro-4-methyl-5-Pyrimidinol

Chemical Property of 2-Chloro-5-hydroxy-4-MethylpyriMidine

Chemical Property:

• PSA: 46.01000
• LogP: 1.14400
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-5-hydroxy-4-methylpyrimidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-5-hydroxy-4-MethylpyriMidine

There total 1 articles about 2-Chloro-5-hydroxy-4-MethylpyriMidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

2-chloro-5-methoxy-4-methylpyrimidine (1245506-61-9) → 2-chloro-4-methylpyrimidin-5-ol (1245506-62-0)

Guidance literature:

With boron tribromide; In dichloromethane; at -78 - 20 ℃; for 16h;

Reference yield: 97.0%

2-chloro-4-methylpyrimidin-5-ol (1245506-62-0) + 2-(4-Fluorophenyl)ethanol (7589-27-7) → 2-chloro-5-(4-fluorophenethoxy)-4-methylpyrimidine

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 2.08333h; Radiolysis;

Reference yield: 61.1%

2-chloro-4-methylpyrimidin-5-ol (1245506-62-0) + (1S,3R)-3-hydroxycyclohexanecarboxylic acid isopropyl ester → isopropyl (1S,3S)-3-((2-chloro-4-methylpyrimidin-5-yl)oxy)cyclohexane-1-carboxylate

Guidance literature:

With tributylphosphine; 1,1'-(Azodicarbonyl)dipiperidin; In 1,4-dioxane; at 75 ℃; for 72h;

upstream raw materials:

2-chloro-5-methoxy-4-methylpyrimidine

Downstream raw materials:

(3R,4S)-4-(2,5-difluorophenyl)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]-4-methylpyrimidin-2-yl}pyrrolidin-3-ylamine p-toluenesulfonate

((3R,4S)-4-(2,5-difluorophenyl)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]-4-methylpyrimidin-2-yl}pyrrolidin-3-yl)carbamic acid tert-butyl ester

(3R,4S)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]-4-methylpyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-ylamine p-toluenesulfonate

[(3R,4S)-1-{5-[1-(3-isopropyl-[1,2,4]oxadiazol-5-yl)piperidin-4-ylmethoxy]-4-methylpyrimidin-2-yl}-4-(2,4,5-trifluorophenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester