4-Oxazolidinecarboxaldehyde, 2-oxo-3-(2-propenyl)-, (4S)- (9CI)

Base Information

• Chemical Name: 4-Oxazolidinecarboxaldehyde, 2-oxo-3-(2-propenyl)-, (4S)- (9CI)
• CAS No.: 340256-53-3
• Molecular Formula: C₇H₉NO₃
• Molecular Weight: 155.153
• Mol file: 340256-53-3.mol

Synonyms:4-Oxazolidinecarboxaldehyde, 2-oxo-3-(2-propenyl)-, (4S)- (9CI)

Chemical Property of 4-Oxazolidinecarboxaldehyde, 2-oxo-3-(2-propenyl)-, (4S)- (9CI)

Chemical Property:

• PSA: 46.61000
• LogP: 0.13000

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Oxazolidinecarboxaldehyde, 2-oxo-3-(2-propenyl)-, (4S)- (9CI)

There total 2 articles about 4-Oxazolidinecarboxaldehyde, 2-oxo-3-(2-propenyl)-, (4S)- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-3-Allyl-2-oxo-oxazolidine-4-carboxylic acid methyl ester (220280-34-2) → (S)-3-Allyl-2-oxo-oxazolidine-4-carbaldehyde (340256-53-3)

Guidance literature:

With diisobutylaluminium hydride; In hexane; dichloromethane; at -78 ℃; for 2h;

DOI:10.1039/b006000n

Reference yield:

(4R)-3-allyl-4-hydroxymethyl-oxazolidin-2-one (723334-87-0) → (S)-3-Allyl-2-oxo-oxazolidine-4-carbaldehyde (340256-53-3)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1016/S0040-4039(01)00635-9

Reference yield:

(S)-3-Allyl-2-oxo-oxazolidine-4-carbaldehyde (340256-53-3) → (8R,8aS)-8-hydroxy-8,8a-dihydro-1H-oxazolo[3,4-a]pyridin-3(5H)-one (448896-88-6)

Guidance literature:

Multi-step reaction with 2 steps

1: CH₂Cl₂

2: Grubbs' catalyst / CH₂Cl₂ / 2 h / 20 °C

With Grubbs catalyst first generation; In dichloromethane;

DOI:10.1016/S0040-4039(01)00635-9

upstream raw materials:

(S)-3-Allyl-2-oxo-oxazolidine-4-carboxylic acid methyl ester

(4R)-3-allyl-4-hydroxymethyl-oxazolidin-2-one

Downstream raw materials:

(8R,8aS)-8-hydroxy-8,8a-dihydro-1H-oxazolo[3,4-a]pyridin-3(5H)-one