Tert-butyl 3-(4-amino-2-methylphenoxy)benzoate

Base Information

Chemical Name:Tert-butyl 3-(4-amino-2-methylphenoxy)benzoate
CAS No.:799242-33-4
Molecular Formula:C18H21NO3
Molecular Weight:299.37
Hs Code.:
DSSTox Substance ID:DTXSID30701795
Wikidata:Q82633564
Mol file:799242-33-4.mol

Synonyms:799242-33-4;SCHEMBL4460715;TERT-BUTYL 3-(4-AMINO-2-METHYLPHENOXY)BENZOATE;DTXSID30701795;ZIXRPDXZWIZWDC-UHFFFAOYSA-N;3-(4-Amino-2-methyl-phenoxy)-benzoic acid tert-butyl ester

Suppliers and Price of Tert-butyl 3-(4-amino-2-methylphenoxy)benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
TERT-BUTYL-3-(4-AMINO-2-METHYLPHENOXY)BENZOATE 95.00%
5MG
$ 505.43

Total 2 raw suppliers

Chemical Property of Tert-butyl 3-(4-amino-2-methylphenoxy)benzoate

Chemical Property:

PSA：61.55000
LogP:4.90600
XLogP3:4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:299.15214353
Heavy Atom Count:22
Complexity:377

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

TERT-BUTYL-3-(4-AMINO-2-METHYLPHENOXY)BENZOATE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C=CC(=C1)N)OC2=CC=CC(=C2)C(=O)OC(C)(C)C

Technology Process of Tert-butyl 3-(4-amino-2-methylphenoxy)benzoate

There total 4 articles about Tert-butyl 3-(4-amino-2-methylphenoxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 799242-32-3
3-(2-methyl-4-nitro-phenoxy)-benzoic acid tert-butyl ester

: 799242-33-4
3-(4-amino-2-methyl-phenoxy)-benzoic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium dihydroxide; In ethanol; at 20 ℃; for 2h; under 2327.23 Torr;
DOI:10.1016/j.bmcl.2007.03.046

Reference yield:

: 455-88-9
5-nitro-2-fluorotoluene

: 799242-33-4
3-(4-amino-2-methyl-phenoxy)-benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.5 h / 10 - 15 °C

1.2: 73 g / dimethylformamide / 20 - 60 °C

2.1: 58.4 g / H₂ / Pd(OH)2 / ethanol / 2 h / 20 °C / 2327.23 Torr

With hydrogen; sodium hydride; palladium dihydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.03.046

Reference yield:

: 57704-54-8
3-hydroxy-benzoic acid tert-butyl ester

: 799242-33-4
3-(4-amino-2-methyl-phenoxy)-benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.5 h / 10 - 15 °C

1.2: 73 g / dimethylformamide / 20 - 60 °C

2.1: 58.4 g / H₂ / Pd(OH)2 / ethanol / 2 h / 20 °C / 2327.23 Torr

With hydrogen; sodium hydride; palladium dihydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2007.03.046