Cyclobutanecarboxamide, N-(2-(7-methoxy-1-naphthalenyl)ethyl)-

Base Information

Chemical Name:Cyclobutanecarboxamide, N-(2-(7-methoxy-1-naphthalenyl)ethyl)-
CAS No.:138113-13-0
Molecular Formula:C₁₈H₂₁NO₂
Molecular Weight:283.37
Hs Code.:
DSSTox Substance ID:DTXSID40160495
Nikkaji Number:J481.055D
Wikidata:Q83028862
ChEMBL ID:CHEMBL288301
Mol file:138113-13-0.mol

Synonyms:S 20642;S-20642

Suppliers and Price of Cyclobutanecarboxamide, N-(2-(7-methoxy-1-naphthalenyl)ethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Cyclobutanecarboxamide, N-(2-(7-methoxy-1-naphthalenyl)ethyl)-

Chemical Property:

Vapor Pressure:4.11E-11mmHg at 25°C
Boiling Point:524.9°Cat760mmHg
Flash Point:271.3°C
Density:1.15g/cm³
XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:283.157228913
Heavy Atom Count:21
Complexity:353

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC2=C(C=CC=C2CCNC(=O)C3CCC3)C=C1

Technology Process of Cyclobutanecarboxamide, N-(2-(7-methoxy-1-naphthalenyl)ethyl)-

There total 7 articles about Cyclobutanecarboxamide, N-(2-(7-methoxy-1-naphthalenyl)ethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 139525-77-2
2-(7-methoxynaphthalen-1-yl)ethanamine hydrochloride

: 5006-22-4
Cyclobutanecarbonyl chloride

: 138113-13-0
N-[2-(7-methoxy-1-naphthyl)ethyl]cyclobutanecarboxamide

Guidance literature:: With potassium carbonate; In chloroform; water; for 0.5h; Ambient temperature;
DOI:10.1021/jm00046a006

Reference yield: 37.0%

: 138113-09-4
2-(7-methoxynaphth-1-yl)ethylamine

: 5006-22-4
Cyclobutanecarbonyl chloride

: 138113-13-0
N-[2-(7-methoxy-1-naphthyl)ethyl]cyclobutanecarboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 50 ℃; for 4h;

Reference yield:

: 6836-22-2
2-(7-methoxynaphthalen-1-yl)acetic acid

: 138113-13-0
N-[2-(7-methoxy-1-naphthyl)ethyl]cyclobutanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / CHCl₃

2: aq. NH₄OH / diethyl ether / 0 °C

3: AlH₄ / diethyl ether

4: K₂CO₃ / H₂O; CHCl₃ / 0 °C

With ammonium hydroxide; thionyl chloride; potassium carbonate; tetrahydridoaluminate; In diethyl ether; chloroform; water;
DOI:10.1021/jm00086a018