3-O-Methyl Estrone Hydrazone

Base Information

• Chemical Name: 3-O-Methyl Estrone Hydrazone
• CAS No.: 105663-60-3
• Molecular Formula: C19H26N2O
• Molecular Weight: 298.42254
• Mol file: 105663-60-3.mol

Synonyms:3-O-Methyl Estrone Hydrazone;3-Methoxy-estra-1,3,5(10)-trien-17-one Hydrazone

Chemical Property of 3-O-Methyl Estrone Hydrazone

Chemical Property:

• PSA: 47.61000
• LogP: 4.56630

Purity/Quality:

97% ^*data from raw suppliers

3-O-Methyl estrone hydrazone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-O-Methyl Estrone Hydrazone

There total 2 articles about 3-O-Methyl Estrone Hydrazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

estrone 3-methyl ether (1624-62-0) → 3-Methoxy-estra-1,3,5(10)-trien-17-on-hydrazone (105663-60-3)

Guidance literature:

With hydrazine hydrate; triethylamine; In ethanol;

Reference yield:

Estrone (53-16-7) → 3-Methoxy-estra-1,3,5(10)-trien-17-on-hydrazone (105663-60-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium hydroxide / dimethyl sulfoxide / 20 °C / Inert atmosphere

2: triethylamine; hydrazine hydrate / ethanol / 6 h / Inert atmosphere; Reflux

With hydrazine hydrate; triethylamine; potassium hydroxide; In ethanol; dimethyl sulfoxide;

DOI:10.1002/chem.201700101

Reference yield:

3-Methoxy-estra-1,3,5(10)-trien-17-on-hydrazone (105663-60-3) → (8R,9S,13S,14S)-17-iodo-3-methoxy-13-methyl-7,8,9,11,12,13,14,15-octahydro-6H-cyclopenta[a]phenanthrene (105644-55-1)

Guidance literature:

With pyridine; iodine; triethylamine; Yield given. Multistep reaction; 1) THF, r.t., 2) 90-100 deg C, 1 h;

upstream raw materials:

estrone 3-methyl ether

Estrone

Downstream raw materials:

(8R,9S,13S,14S)-17-iodo-3-methoxy-13-methyl-7,8,9,11,12,13,14,15-octahydro-6H-cyclopenta[a]phenanthrene

3-methoxyestra-1,3,5⁽¹⁰⁾,16-tetraene