2-METHYL-7-NITRO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE

Base Information

• Chemical Name: 2-METHYL-7-NITRO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE
• CAS No.: 85160-82-3
• Molecular Formula: C₉H₈N₂O₄
• Molecular Weight: 208.174
• Hs Code.: 2934999090
• Mol file: 85160-82-3.mol

Synonyms:2-METHYL-7-NITRO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE;2-Methyl-7-nitro-2H-1,4-benzoxazin-3(4H)-one, 97%

Chemical Property of 2-METHYL-7-NITRO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE

Chemical Property:

• PSA: 84.15000
• LogP: 1.97540

Purity/Quality:

98%min ^*data from raw suppliers

2-Methyl-7-nitro-2H-1,4-benzoxazin-3(4H)-one ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHYL-7-NITRO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE

There total 5 articles about 2-METHYL-7-NITRO-2H-BENZO[B][1,4]OXAZIN-3(4H)-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

Ethyl 2-bromopropionate (535-11-5,41978-69-2) + 5-Nitro-2-aminophenol (121-88-0) → 2-methyl-7-nitro-2-hydro-1,4-benzomorpholin-3-(4-hydro)-one (85160-82-3)

Guidance literature:

With potassium fluoride; In N,N-dimethyl-formamide; at 50 - 60 ℃; for 6h;

DOI:10.1055/s-1982-30037

Reference yield: 77.0%

2-chloropropionyl chloride (7623-09-8) + 5-Nitro-2-aminophenol (121-88-0) → 2-methyl-7-nitro-2-hydro-1,4-benzomorpholin-3-(4-hydro)-one (85160-82-3)

Guidance literature:

With sodium hydrogencarbonate; In water; Heating;

DOI:10.1021/jm061329j

Reference yield: 75.0%

Methyl 2-bromopropionate (5445-17-0) + 5-Nitro-2-aminophenol (121-88-0) → 2-methyl-7-nitro-2-hydro-1,4-benzomorpholin-3-(4-hydro)-one (85160-82-3)

Guidance literature:

Methyl 2-bromopropionate; With potassium fluoride; In N,N-dimethyl-formamide; at 10 - 35 ℃; for 0.25h;

5-Nitro-2-aminophenol; In N,N-dimethyl-formamide; at 10 - 60 ℃; for 20h;

upstream raw materials:

Ethyl 2-bromopropionate

5-Nitro-2-aminophenol

2-chloropropionyl chloride

Methyl 2-bromopropionate

Downstream raw materials:

(+/-)-3,4-dihydro-2-methyl-7-nitro-2H-1,4-benzoxazine

7-amino-2-methyl-2H-benzo[b][1,4]oxazin-3(4H)-one