(S)-2-(4,5-Dihydro-4-isopropyl-2-oxazolyl)quinoline

Base Information

• Chemical Name: (S)-2-(4,5-Dihydro-4-isopropyl-2-oxazolyl)quinoline
• CAS No.: 226387-11-7
• Molecular Formula: C₁₅H₁₆N₂O
• Molecular Weight: 240.305
• Mol file: 226387-11-7.mol

Synonyms:(S)-2-(4,5-Dihydro-4-isopropyl-2-oxazolyl)quinoline;(S)-2-(4,5-Dihydro-4-isopropyl-2-oxazolyl)quinoline 97%;(S)-i-PrQuinox

Chemical Property of (S)-2-(4,5-Dihydro-4-isopropyl-2-oxazolyl)quinoline

Chemical Property:

• Melting Point: 75-80°C
• Boiling Point: 395.0±15.0 °C(Predicted)
• PKA: 3.27±0.61(Predicted)
• PSA: 34.48000
• Density: 1.18±0.1 g/cm3(Predicted)
• LogP: 2.47180
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

(S)-2-(4,5-Dihydro-4-isopropyl-2-oxazolyl)quinoline 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-2-(4,5-Dihydro-4-isopropyl-2-oxazolyl)quinoline

There total 7 articles about (S)-2-(4,5-Dihydro-4-isopropyl-2-oxazolyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

quinoline-2-carbonitrile (1436-43-7) + (S)-valinol (2026-48-4,473-75-6) → (S)-4-isopropyl-2-(quinolin-2-yl)-4,5-dihydrooxazole (1802928-40-0,226387-11-7)

Guidance literature:

In neat (no solvent); at 150 ℃; for 1h; Microwave irradiation;

DOI:10.1016/j.tetasy.2014.08.010

Reference yield:

C15H17ClN2O → (S)-4-isopropyl-2-(quinolin-2-yl)-4,5-dihydrooxazole (1802928-40-0,226387-11-7)

Guidance literature:

With sodium hydroxide; In ethanol; Reflux;

DOI:10.1016/j.tetlet.2010.07.084

Reference yield:

C15H18N2O2 → (S)-4-isopropyl-2-(quinolin-2-yl)-4,5-dihydrooxazole (1802928-40-0,226387-11-7)

Guidance literature:

With TEA; p-toluenesulfonyl chloride; dmap; In dichloromethane; for 12h; Heating;

DOI:10.1021/ja070263u

upstream raw materials:

quinoline-2-carbonitrile

(S)-valinol

quinolin-2-ylcarbonyl chloride

quinoline-2-carboxylic acid

Refernces

• 1、 Guo, Jun,Liu, Heng,Bi, Jifu,Zhang, Chunyu,Zhang, Hexin,Bai, Chenxi,Hu, Yanming,Zhang, Xuequan. "Pyridine-oxazoline and quinoline-oxazoline ligated cobalt complexes: Synthesis, characterization, and 1,3-butadiene polymerization behaviors". . p. 305 - 312. Retrieved 2015/08/06.
• 2、 Jiang, Feng,Wu, Zhengxing,Zhang, Wanbin. "Pd-catalyzed asymmetric aza-Wacker-type cyclization reaction of olefinic tosylamides". scheme or table. p. 5124 - 5126. Retrieved 2010/11/16.