L-(+)-Chloramphenicol palmitate

Base Information

• Chemical Name: L-(+)-Chloramphenicol palmitate
• CAS No.: 39909-95-0
• Molecular Formula: C₂₇H₄₂Cl₂N₂O₆
• Molecular Weight: 561.546
• Mol file: 39909-95-0.mol

Synonyms:Hexadecanoic acid, 2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl ester, [S-(R*,R*)]-;L-(+)-Chloramphenicol palmitate;Palmitic acid, a-ester with L-threo-chloramphenicol (6CI)

Chemical Property of L-(+)-Chloramphenicol palmitate

Chemical Property:

• PSA: 121.45000
• LogP: 7.85530

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-(+)-Chloramphenicol palmitate

There total 6 articles about L-(+)-Chloramphenicol palmitate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chlorampenicol (56-75-7,134-90-7,579-51-1,2787-09-9,3419-87-2,7384-89-6,7387-98-6,50762-99-7,126787-77-7,140694-65-1,85666-84-8) + n-hexadecanoyl chloride (112-67-4) → (1RS,2RS)-2-(2,2-dichloro-acetylamino)-1-(4-nitro-phenyl)-3-palmitoyloxy-propan-1-ol (530-43-8,39909-95-0,106322-62-7,125637-16-3)

Guidance literature:

With pyridine; N,N-dimethyl-formamide;

DOI:10.1021/ja01606a007

Reference yield:

→ (1RS,2RS)-2-(2,2-dichloro-acetylamino)-1-(4-nitro-phenyl)-3-palmitoyloxy-propan-1-ol (530-43-8,39909-95-0,106322-62-7,125637-16-3)

Guidance literature:

/BRN= 3229772/;

Reference yield:

dichloroacetic acid methyl ester (116-54-1) + (1S,2S)-2-amino-1-(4-nitro-phenyl)-3-palmitoyloxy-propan-1-ol (47711-23-9) → (1S,2S)-2-(2,2-dichloro-acetylamino)-1-(4-nitro-phenyl)-3-palmitoyloxy-propan-1-ol (39909-95-0)

Guidance literature:

With methanol;

upstream raw materials:

dichloroacetic acid methyl ester

(1S,2S)-2-amino-1-(4-nitro-phenyl)-3-palmitoyloxy-propan-1-ol

(1S,2S)-2-amino-1-(4-nitro-phenyl)-3-palmitoyloxy-propan-1-ol; hydrochloride

dichloroacetic anhydride