N-tert-butyl-4'-forMylbiphenyl-2-sulfonaMide

Base Information

• Chemical Name: N-tert-butyl-4'-forMylbiphenyl-2-sulfonaMide
• CAS No.: 851902-28-8
• Molecular Formula: C₁₇H₁₉NO₃S
• Molecular Weight: 317.409
• Mol file: 851902-28-8.mol

Synonyms:N-tert-butyl-4'-forMylbiphenyl-2-sulfonaMide;N-(tert-Butyl)-4'-formyl-[1,1'-biphenyl]-2-sulfonamide

Chemical Property of N-tert-butyl-4'-forMylbiphenyl-2-sulfonaMide

Chemical Property:

• PSA: 71.62000
• LogP: 4.71460

Purity/Quality:

97% ^*data from raw suppliers

N-tert-Butyl-4'-formylbiphenyl-2-sulfonamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-tert-butyl-4'-forMylbiphenyl-2-sulfonaMide

There total 1 articles about N-tert-butyl-4'-forMylbiphenyl-2-sulfonaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-formylphenylboronic acid, (87199-17-5) + N-(1,1-dimethylethyl)-2-bromobenzenesulfonamide (138733-50-3) → 4'-formylbiphenyl-2-sulfonic acid t-butylamide (851902-28-8)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; In toluene; at 85 ℃;

DOI:10.1016/j.bmcl.2005.02.002

Reference yield:

4'-formylbiphenyl-2-sulfonic acid t-butylamide (851902-28-8) → trans-1-(RS)-[4-(2-aminosulfonylphenyl)]-benzylaminocarbonyl-2-(SR)-benzylaminocarbonylcyclopentane

Guidance literature:

Multi-step reaction with 5 steps

1.1: NH₂OH; Na₂CO₃ / ethanol

2.1: H₂ / Pd/C / ethanol / 2585.74 Torr

3.1: 92 percent / TFA / 50 °C

4.1: CDI / tetrahydrofuran

4.2: tetrahydrofuran

5.1: EDC; HOBt; DIEA / tetrahydrofuran

With hydrogen; hydroxylamine; sodium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bmcl.2005.02.002

Reference yield:

4'-formylbiphenyl-2-sulfonic acid t-butylamide (851902-28-8) → trans-1-(RS)-[4-(2-aminosulfonylphenyl)]-benzylaminocarbonyl-2-(SR)-(4-methoxy)-benzylaminocarbonyl cyclopentane

Guidance literature:

Multi-step reaction with 5 steps

1.1: NH₂OH; Na₂CO₃ / ethanol

2.1: H₂ / Pd/C / ethanol / 2585.74 Torr

3.1: 92 percent / TFA / 50 °C

4.1: CDI / tetrahydrofuran

4.2: tetrahydrofuran

5.1: EDC; HOBt; DIEA / tetrahydrofuran

With hydrogen; hydroxylamine; sodium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol;

DOI:10.1016/j.bmcl.2005.02.002

upstream raw materials:

4-formylphenylboronic acid,

N-(1,1-dimethylethyl)-2-bromobenzenesulfonamide

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