P-Trifluoromethyl phenyl acetonite

Base Information

• Chemical Name: P-Trifluoromethyl phenyl acetonite
• CAS No.: 1036762-58-9
• Molecular Formula: C10H9F3O2
• Molecular Weight: 218.17
• Mol file: 1036762-58-9.mol

Synonyms:P-Trifluoromethyl phenyl acetonite

Chemical Property of P-Trifluoromethyl phenyl acetonite

Chemical Property:

• PSA: 26.30000
• LogP: 2.67320

Purity/Quality:

98%min ^*data from raw suppliers

1-[4-(Trifluoromethyl)phenoxy]propan-2-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of P-Trifluoromethyl phenyl acetonite

There total 2 articles about P-Trifluoromethyl phenyl acetonite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.8%

→ C10H9F3O2 (1036762-58-9)

Guidance literature:

With potassium carbonate; In acetone; at 20 ℃; for 0.5h;

With potassium iodide; In acetone; for 3h; Reflux;

Reference yield: 93.0%

4-hydroxybenzotrifluoride (402-45-9) + chloroacetone (78-95-5) → C10H9F3O2 (1036762-58-9)

Guidance literature:

With potassium carbonate; sodium iodide; In acetone; at 80 ℃; for 2h; Inert atmosphere;

DOI:10.1039/d1cc05684k

Reference yield: 98.0%

C10H9F3O2 (1036762-58-9) + vinylmagnesium chloride (3536-96-7) → C12H13F3O2

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 0.5h;

DOI:10.1021/jacs.7b11299

upstream raw materials:

4-hydroxybenzotrifluoride

chloroacetone

Downstream raw materials:

C₁₁H₁₁F₃N₂O

1-methyl-2-(p-(trifluoromethyl)phenoxy)ethylamine