(R)-2-(4-benzylpiperazin-2-yl)ethanol-2HCl

Base Information

• Chemical Name: (R)-2-(4-benzylpiperazin-2-yl)ethanol-2HCl
• CAS No.: 857334-79-3
• Molecular Formula: C13H22Cl2N2O
• Molecular Weight: 220.315
• Mol file: 857334-79-3.mol

Synonyms:(R)-2-(4-benzylpiperazin-2-yl)ethanol-2HCl;(R)-2-(4-Benzylpiperazin-2-yl)ethanol

Chemical Property of (R)-2-(4-benzylpiperazin-2-yl)ethanol-2HCl

Chemical Property:

• Boiling Point: 366.7±27.0 °C(Predicted)
• PKA: 15.11±0.10(Predicted)
• Density: 1.064±0.06 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

(R)-2-(4-BENZYLPIPERAZIN-2-YL)ETHANOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-2-(4-benzylpiperazin-2-yl)ethanol-2HCl

There total 7 articles about (R)-2-(4-benzylpiperazin-2-yl)ethanol-2HCl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(R)-benzyl 2-(4-benzyl-3,6-dioxopiperazin-2-yl)acetate (857334-77-1) → (R)-2-(4-benzylpiperazin-2-yl)ethanol (857334-79-3,517866-77-2)

Guidance literature:

(R)-benzyl 2-(4-benzyl-3,6-dioxopiperazin-2-yl)acetate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 20 - 60 ℃; Heating / reflux;

With hydrogenchloride; In chloroform; water;

Reference yield: 21.1%

(R)-tert-butyl 4-benzyl-2-(2-hydroxyethyl)piperazine-1-carboxylate → (R)-2-(4-benzylpiperazin-2-yl)ethanol (857334-79-3,517866-77-2)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

Reference yield:

(R)-methyl 2-(4-benzyl-3,6-dioxopiperazin-2-yl)acetate → (R)-2-(4-benzylpiperazin-2-yl)ethanol (857334-79-3,517866-77-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; Reflux; Cooling with ice;

upstream raw materials:

(R)-benzyl 2-(4-benzyl-3,6-dioxopiperazin-2-yl)acetate

ethyl 2-(benzylamino)acetate

(R)-dimethyl 2-(2-chloroacetamido)succinate

Downstream raw materials:

(R)-2-(piperazin-2-yl)ethan-1-ol