(R)-2-(Piperazin-2-yl)ethanol

Base Information

Chemical Name:(R)-2-(Piperazin-2-yl)ethanol
CAS No.:660862-46-4
Molecular Formula:C6H14N2O
Molecular Weight:130.19
Hs Code.:
UNII:91U2INQ46B
DSSTox Substance ID:DTXSID80364016
Mol file:660862-46-4.mol

Synonyms:(R)-2-(Piperazin-2-yl)ethanol;660862-46-4;2-[(2R)-piperazin-2-yl]ethanol;2-Piperazineethanol, (2R)-;(R)-2-Piperazin-2-ylethanol;91U2INQ46B;2-(2-Hydroxyethyl)piperazine, (2R)-;(R)-2-Piperazin-2-yl-ethanol;UNII-91U2INQ46B;SCHEMBL4749933;DTXSID80364016;(2R)-2-(2-hydroxyethyl)piperazine;AT37354;(R)-2-(PIPERAZIN-2-YL)ETHAN-1-OL;Q27271427

Suppliers and Price of (R)-2-(Piperazin-2-yl)ethanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
(R)-2-(Piperazin-2-yl)ethanol 95+%
1g
$ 1144.00

Chemenu
(R)-2-(Piperazin-2-yl)ethanol 95%
1g
$ 1078.00

American Custom Chemicals Corporation
(R)-2-(PIPERAZIN-2-YL)ETHANOL 95.00%
1G
$ 1380.23

Total 3 raw suppliers

Chemical Property of (R)-2-(Piperazin-2-yl)ethanol

Chemical Property:

Boiling Point:270.4±20.0 °C(Predicted)
PKA:15.11±0.10(Predicted)
PSA：44.29000
Density:0.974±0.06 g/cm3(Predicted)
LogP:-0.41220
XLogP3:-1.1
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:130.110613074
Heavy Atom Count:9
Complexity:77.5

Purity/Quality:

95% ^*data from raw suppliers

(R)-2-(Piperazin-2-yl)ethanol 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNC(CN1)CCO
Isomeric SMILES:C1CN[C@@H](CN1)CCO

Technology Process of (R)-2-(Piperazin-2-yl)ethanol

There total 8 articles about (R)-2-(Piperazin-2-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 857334-79-3,517866-77-2
(R)-2-(4-benzylpiperazin-2-yl)ethanol

: 660862-46-4
(R)-2-(piperazin-2-yl)ethan-1-ol

Guidance literature:: With hydrogen; 20% Pd(OH)2 on carbon; In methanol; under 2585.81 Torr;

Reference yield: 74.0%

: (R)-2-(1,4-ditosylpiperazin-2-yl)ethan-1-ol

: 660862-46-4
(R)-2-(piperazin-2-yl)ethan-1-ol

Guidance literature:: With methanol; magnesium; In dichloromethane; at 20 ℃; Inert atmosphere; Schlenk technique;
DOI:10.1021/acs.orglett.0c01490

Reference yield:

: 1485770-18-0
(R)-dimethyl 2-(2-chloroacetamido)succinate

: 660862-46-4
(R)-2-(piperazin-2-yl)ethan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / acetonitrile / 124 h / 65 °C / Cooling with ice

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Inert atmosphere; Heating

3: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / 2844.39 - 3361.55 Torr / Autoclave

With lithium aluminium tetrahydride; palladium 10% on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; methanol; acetonitrile;
DOI:10.1016/j.tetlet.2018.04.030