tert-butyl 4-(2-((4H-1,2,4-triazol-4-yl)methyl)phenyl)piperazine-1-carboxylate

Base Information

Chemical Name:tert-butyl 4-(2-((4H-1,2,4-triazol-4-yl)methyl)phenyl)piperazine-1-carboxylate
CAS No.:179250-42-1
Molecular Formula:C₁₈H₂₅N₅O₂
Molecular Weight:343.429
Hs Code.:
Mol file:179250-42-1.mol

Synonyms:tert-butyl 4-(2-((4H-1,2,4-triazol-4-yl)methyl)phenyl)piperazine-1-carboxylate

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Chemical Property of tert-butyl 4-(2-((4H-1,2,4-triazol-4-yl)methyl)phenyl)piperazine-1-carboxylate

Chemical Property:

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Technology Process of tert-butyl 4-(2-((4H-1,2,4-triazol-4-yl)methyl)phenyl)piperazine-1-carboxylate

There total 6 articles about tert-butyl 4-(2-((4H-1,2,4-triazol-4-yl)methyl)phenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 446-52-6
2-Fluorobenzaldehyde

: 179250-42-1
4-(2-[1,2,4]triazol-4-ylmethyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / K₂CO₃ / dimethylsulfoxide / 130 °C

2: 74 percent / NaBH₄ / methanol / 0 °C

3: 96 percent / Et₃N / 0 °C

4: acetonitrile / 25 °C

5: aq. NaOH

With sodium hydroxide; sodium tetrahydroborate; potassium carbonate; triethylamine; In methanol; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/S0960-894X(03)00796-0

Reference yield:

: 57260-71-6
1-t-Butoxycarbonylpiperazine

: 179250-42-1
4-(2-[1,2,4]triazol-4-ylmethyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 93 percent / K₂CO₃ / dimethylsulfoxide / 130 °C

2: 74 percent / NaBH₄ / methanol / 0 °C

3: 96 percent / Et₃N / 0 °C

4: acetonitrile / 25 °C

5: aq. NaOH

With sodium hydroxide; sodium tetrahydroborate; potassium carbonate; triethylamine; In methanol; dimethyl sulfoxide; acetonitrile;
DOI:10.1016/S0960-894X(03)00796-0

Reference yield:

: 174855-57-3
tert-butyl 4-(2-formylphenyl)piperazinecarboxylate

: 179250-42-1
4-(2-[1,2,4]triazol-4-ylmethyl-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 74 percent / NaBH₄ / methanol / 0 °C

2: 96 percent / Et₃N / 0 °C

3: acetonitrile / 25 °C

4: aq. NaOH

With sodium hydroxide; sodium tetrahydroborate; triethylamine; In methanol; acetonitrile;
DOI:10.1016/S0960-894X(03)00796-0