174855-57-3

Basic information

• Product Name: 4-(2-FORMYLPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: 1-TERT-BUTOXYCARBONYL-4-(2-FORMYLPHENYL)PIPERAZINE;2-(N-BOC-PIPERAZIN-1-YL)BENZALDEHYDE;1-BOC-4-(2-FORMYLPHENYL)PIPERAZINE;1-(2-FORMYL-PHENYL)-PIPERAZINE-4-CARBOXYLIC ACID TERT-BUTYL ESTER;4-(2-FORMYLPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;4-(2-FORMYLPHENYL)PIPERAZINE, N1-BOC PROTECTED;TERT-BUTYL 4-(2-FORMYLPHENYL)-1-PIPERAZINECARBOXYLATE;TERT-BUTYL 4-(2-FORMYLPHENYL)PIPERAZINE-1-CARBOXYLATE
• CAS NO: 174855-57-3
• Molecular Formula: C₁₆H₂₂N₂O₃
• Molecular Weight: 290.36
• Product Categories: piperazines;Aldehydes;Building Blocks;C13-C60;C16 to C29;Carbonyl Compounds;Chemical Synthesis;Heterocyclic Building Blocks;Organic Building Blocks
• Mol File: 174855-57-3.mol
• Article Data: 16

Chemical Properties

• Melting Point: 86-90 °C(lit.)
• Boiling Point: 425.3 °C at 760 mmHg
• Flash Point: 211 °C
• Appearance: Solid
• Density: 1.154 g/cm₃
• Vapor Pressure: 1.93E-07mmHg at 25°C
• Refractive Index: 1.561
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 2.48±0.10(Predicted)
• CAS DataBase Reference: 4-(2-FORMYLPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-FORMYLPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(174855-57-3)
• EPA Substance Registry System: 4-(2-FORMYLPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(174855-57-3)

Safety Data

• Hazard Codes: T,Xi
• Statements: 25-43
• Safety Statements: 36/37-45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• HazardClass: 6.1
• Hazardous Substances Data: 174855-57-3(Hazardous Substances Data)

Usage

Uses

1-Boc-4-(2-formylphenyl)piperazine is used in the synthesis of melanocortin subtype-4 receptor (MC4R) agonists. MC4R is located in the hypothalamus and helps to regulate metabolism, feeding and reproductive behavior. Agonists to these receptors have shown to decrease feeding behaviors.

InChI:InChI=1/C16H22N2O3/c1-16(2,3)21-15(20)18-10-8-17(9-11-18)14-7-5-4-6-13(14)12-19/h4-7,12H,8-11H2,1-3H3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 111373-03-6 2-(piperazin-1-yl)benzonitrile 
• 736991-52-9 2-(Piperazin-1-yl)benzaldehyde 
• 446-52-6 2-Fluorobenzaldehyde 
• 57260-71-6 1-t-Butoxycarbonylpiperazine 

Downstream Products

• 444582-74-5 1-tert-butoxycarbonyl-4-{2-[hydroxy(1-methyl-1H-imidazol-2-yl)methyl]phenyl}piperazine 
• 444582-64-3 1-N-tert-butoxycarbonyl-4-(2-((diethylamino)methyl)phenyl)piperazine 
• 736991-52-9 2-(Piperazin-1-yl)benzaldehyde 
• 1253936-71-8 4-[2-(2-amino-4-trifluoromethyl-phenylcarbamoyl)phenyl]piperazine-1-carboxylic acid tert-butyl ester 
• 1253936-87-6 2-(3,5-dimethyl-pyrazol-1-yl)-1-{4-[2-(5-trifluoromethyl-1H-benzoimidazol-2-yl)phenyl]piperazin-1-yl}ethanone 
• 1253936-72-9 N-(2-amino-4-trifluoromethyl-phenyl)-2-{4-[2-(3,5-dimethyl-pyrazol-1-yl)acetyl]piperazin-1-yl}benzamide 
• 1203793-75-2 (Z)-tert-butyl 4-(2-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)piperazine-1-carboxylate 
• 444582-90-5 2-{4-[(tert-butoxy)carbonyl]piperazin-1-yl}benzoic acid 
• 728862-46-2 1-(2-pyrrolidin-1-ylmethyl-phenyl)-piperazine 

Relevant articles and documents

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