4-Piperidineacetic acid, .alpha.-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester

Base Information

• Chemical Name: 4-Piperidineacetic acid, .alpha.-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester
• CAS No.: 219832-76-5
• Molecular Formula: C13H24N2O4
• Molecular Weight: 272.345
• Hs Code.: 2933399090
• Mol file: 219832-76-5.mol

Synonyms:4-Piperidineacetic acid, .alpha.-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester;alpha-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-piperidineacetic acid methyl ester;Methyl 2-((tert-butoxycarbonyl)aMino)-2-(piperidin-4-yl)acetate;a-(Boc-aMino)-4-piperidineacetic acid Methyl ester HCl;4-Piperidineacetic acid, α-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester;METHYL 2-(BOC-AMINO)-2-(PIPERIDIN-4-YL)ACETATE

Chemical Property of 4-Piperidineacetic acid, .alpha.-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester

Chemical Property:

• PSA: 80.15000
• Density: 1.076
• LogP: 1.58550
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

97% ^*data from raw suppliers

Methyl2-((tert-butoxycarbonyl)amino)-2-(piperidin-4-yl)acetate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Piperidineacetic acid, .alpha.-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester

There total 3 articles about 4-Piperidineacetic acid, .alpha.-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl 4-oxo-1-piperidinecarboxylate (19099-93-5) → methyl 2-((tert-butoxycarbonyl)amino)-2-(piperidin-4-yl)acetate (219832-76-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / DBU / CH₂Cl₂ / 24 h

2: H₂ / Pd/C / methanol / 2.5 h

With hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1016/S0960-894X(98)00613-1

Reference yield:

4-(tert-Butoxycarbonylamino-methoxycarbonyl-methylene)-piperidine-1-carboxylic acid benzyl ester (219832-75-4) → methyl 2-((tert-butoxycarbonyl)amino)-2-(piperidin-4-yl)acetate (219832-76-5)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 2.5h;

DOI:10.1016/S0960-894X(98)00613-1

Reference yield:

trimethyl 2-(tert-butoxycarbonylamino)phosphonoacetate (121056-95-9,89524-98-1) → methyl 2-((tert-butoxycarbonyl)amino)-2-(piperidin-4-yl)acetate (219832-76-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / DBU / CH₂Cl₂ / 24 h

2: H₂ / Pd/C / methanol / 2.5 h

With hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1016/S0960-894X(98)00613-1

upstream raw materials:

4-(tert-Butoxycarbonylamino-methoxycarbonyl-methylene)-piperidine-1-carboxylic acid benzyl ester

benzyl 4-oxo-1-piperidinecarboxylate

trimethyl 2-(tert-butoxycarbonylamino)phosphonoacetate

Downstream raw materials:

(6S,8aS)-4-Oxo-2-(3-phenyl-propionyl)-octahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid [(S)-1-(1-carbamimidoyl-piperidin-4-yl)-2-oxo-2-thiazol-2-yl-ethyl]-amide

(6S,8aS)-4-Oxo-2-(3-phenyl-propionyl)-octahydro-pyrrolo[1,2-a]pyrazine-6-carboxylic acid [(R)-1-(1-carbamimidoyl-piperidin-4-yl)-2-oxo-2-thiazol-2-yl-ethyl]-amide