7-Phenyl-thieno[2,3-c]pyridine

Base Information

• Chemical Name: 7-Phenyl-thieno[2,3-c]pyridine
• CAS No.: 100067-45-6
• Molecular Formula: C13H9NS
• Molecular Weight: 211.287
• Mol file: 100067-45-6.mol

Synonyms:7-Phenyl-thieno[2,3-c]pyridine

Chemical Property of 7-Phenyl-thieno[2,3-c]pyridine

Chemical Property:

• Boiling Point: 150 °C (0.5 mmHg)
• PSA: 41.13000
• LogP: 3.96330

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-Phenyl-thieno[2,3-c]pyridine

There total 8 articles about 7-Phenyl-thieno[2,3-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-oxo-7-phenyl-2,3-dihydrothieno<2,3-c>pyridine (100037-75-0) → 7-phenyl-thieno[2,3-c]pyridine (100067-45-6)

Guidance literature:

With acetic anhydride; for 4h; Heating;

DOI:10.1021/jo00282a006

Reference yield:

2-(3-thienyl)ethylamine (59311-67-0) → 7-phenyl-thieno[2,3-c]pyridine (100067-45-6)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. NaOH solution

2: P₂O₅; POCl₃; xylene

3: palladium/charcoal

With sodium hydroxide; palladium on activated charcoal; phosphorus pentoxide; xylene; trichlorophosphate;

DOI:10.1021/ja01145a117

Reference yield:

5-phenyl-1,2,4-triazine-6-thione (99702-46-2) → 7-phenyl-thieno[2,3-c]pyridine (100067-45-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 85 percent / triethylamine / tetrahydrofuran / 24 h / Ambient temperature

2: 85percent m-chloroperbenzoic acid (mcpba) / CH₂Cl₂ / 1 h / Ambient temperature

3: CH₂Cl₂ / 4 h / Ambient temperature

4: 93 percent / acetic anhydride / 4 h / Heating

With acetic anhydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jo00282a006

upstream raw materials:

7-phenyl-4,5-dihydrothieno<2,3-c>pyridine

1-oxo-7-phenyl-2,3-dihydrothieno<2,3-c>pyridine

5-phenyl-1,2,4-triazine-6-thione

6-(3-butynylthio)-5-phenyl-1,2,4-triazine