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59311-67-0

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59311-67-0 Usage

Description

2-(3-Thienyl)ethanamine, also known as 3-Thienylethylamine, is a chemical compound belonging to the class of aromatic amines. It is a derivative of thiofuran, characterized by its thienyl group, which consists of a five-membered sulfur-containing ring. 2-(3-THIENYL)ETHANAMINE has potential applications in pharmaceutical and medical research due to its ability to interact with biological systems through its amine functional group. The thienyl group may also confer specific biological activities that could be of interest for medicinal chemistry. Its synthesis and structural properties are of interest to researchers studying the potential pharmaceutical and biological activities of 2-(3-Thienyl)ethanamine.

Uses

Used in Pharmaceutical Industry:
2-(3-Thienyl)ethanamine is used as a pharmaceutical intermediate for the development of various drugs. Its amine functional group allows for the formation of various chemical bonds and interactions with biological systems, making it a valuable component in the synthesis of pharmaceutical compounds.
Used in Medical Research:
2-(3-Thienyl)ethanamine is used as a research compound in the field of medical research. Its unique structure and potential biological activities make it an interesting candidate for studying its effects on various biological processes and its potential use in the development of new therapeutic agents.
Used in Medicinal Chemistry:
2-(3-Thienyl)ethanamine is used as a building block in the design and synthesis of novel compounds with potential medicinal properties. The thienyl group may confer specific biological activities that could be exploited for the development of new drugs with unique mechanisms of action.

Check Digit Verification of cas no

The CAS Registry Mumber 59311-67-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,9,3,1 and 1 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 59311-67:
(7*5)+(6*9)+(5*3)+(4*1)+(3*1)+(2*6)+(1*7)=130
130 % 10 = 0
So 59311-67-0 is a valid CAS Registry Number.
InChI:InChI=1/C6H9NS/c7-3-1-6-2-4-8-5-6/h2,4-5H,1,3,7H2

59311-67-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(Thiophen-3-yl)ethanamine

1.2 Other means of identification

Product number -
Other names 2-thiophen-3-ylethanamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:59311-67-0 SDS

59311-67-0Relevant articles and documents

Unified Synthesis of Polycyclic Alkaloids by Complementary Carbonyl Activation**

Christmann, Mathias,He, Guoli,List, Benjamin

supporting information, p. 13591 - 13596 (2021/05/07)

A complementary dual carbonyl activation strategy for the synthesis of polycyclic alkaloids has been developed. Successful applications include the synthesis of tetracyclic alkaloids harmalanine and harmalacinine, pentacyclic indoloquinolizidine alkaloid nortetoyobyrine, and octacyclic β-carboline alkaloid peganumine A. The latter synthesis features a protecting-group-free assembly and an asymmetric disulfonimide-catalyzed cyclization. Furthermore, formal syntheses of hirsutine, deplancheine, 10-desbromoarborescidine A, and oxindole alkaloids rhynchophylline and isorhynchophylline have been achieved. Finally, a concise synthesis of berberine alkaloid ilicifoline B was completed.

Reaction of Diisobutylaluminum Borohydride, a Binary Hydride, with Selected Organic Compounds Containing Representative Functional Groups

Amberchan, Gabriella,Snelling, Rachel A.,Moya, Enrique,Landi, Madison,Lutz, Kyle,Gatihi, Roxanne,Singaram, Bakthan

supporting information, p. 6207 - 6227 (2021/05/06)

The binary hydride, diisobutylaluminum borohydride [(iBu)2AlBH4], synthesized from diisobutylaluminum hydride (DIBAL) and borane dimethyl sulfide (BMS) has shown great potential in reducing a variety of organic functional groups. This unique binary hydride, (iBu)2AlBH4, is readily synthesized, versatile, and simple to use. Aldehydes, ketones, esters, and epoxides are reduced very fast to the corresponding alcohols in essentially quantitative yields. This binary hydride can reduce tertiary amides rapidly to the corresponding amines at 25 °C in an efficient manner. Furthermore, nitriles are converted into the corresponding amines in essentially quantitative yields. These reactions occur under ambient conditions and are completed in an hour or less. The reduction products are isolated through a simple acid-base extraction and without the use of column chromatography. Further investigation showed that (iBu)2AlBH4 has the potential to be a selective hydride donor as shown through a series of competitive reactions. Similarities and differences between (iBu)2AlBH4, DIBAL, and BMS are discussed.

Design, synthesis and evaluation of novel N-phenylbutanamide derivatives as KCNQ openers for the treatment of epilepsy

Yang, Shaoning,Lu, Dingqiang,Ouyang, Pingkai

supporting information, p. 3004 - 3008 (2018/07/31)

KCNQ (Kv7) has emerged as a validated target for the development of novel anti-epileptic drugs. In this paper, a series of novel N-phenylbutanamide derivatives were designed, synthesized and evaluated as KCNQ openers for the treatment of epilepsy. These compounds were evaluated for their KCNQ opening activity in vitro and in vivo. Several compounds were found to be potent KCNQ openers. Compound 1 with favorable in vitro activity was submitted to evaluation in vivo. Results showed that compound 1 owned significant anti-convulsant activity with no adverse effects. It was also found to posses favorable pharmacokinetic profiles in rat. This research may provide novel potent compounds for the discovery of KCNQ openers in treating epilepsy.

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