2-Pyridin-2-yl-Malonic acid di-tert-butyl ester

Base Information

• Chemical Name: 2-Pyridin-2-yl-Malonic acid di-tert-butyl ester
• CAS No.: 1104643-39-1
• Molecular Formula: C₁₆H₂₃NO₄
• Molecular Weight: 293.363
• Hs Code.: 2933399090
• Mol file: 1104643-39-1.mol

Synonyms:2-Pyridin-2-yl-Malonic acid di-tert-butyl ester;Di-tert-butyl 2-(pyridin-2-yl)Malonate;di-tert-butyl (pyridin-2-yl)malonate

Chemical Property of 2-Pyridin-2-yl-Malonic acid di-tert-butyl ester

Chemical Property:

• PSA: 65.49000
• LogP: 2.84860
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-PYRIDIN-2-YL-MALONIC ACID DI-TERT-BUTYL ESTER 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyridin-2-yl-Malonic acid di-tert-butyl ester

There total 2 articles about 2-Pyridin-2-yl-Malonic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

α-picoline (109-06-8) + di-tert-butyl dicarbonate (24424-99-5) → di-tert-butyl (pyridin-2-yl)malonate (1104643-39-1)

Guidance literature:

α-picoline; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃; for 0.75h;

di-tert-butyl dicarbonate; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2h;

DOI:10.1016/j.tet.2008.10.089

Reference yield: 29.0%

α-picoline (109-06-8) + di-tert-butyl dicarbonate (24424-99-5) → di-tert-butyl (pyridin-2-yl)malonate (1104643-39-1) + tert-butyl 2-(pyridin-2-yl)acetate (150059-62-4)

Guidance literature:

α-picoline; With n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at -78 ℃; for 1h;

di-tert-butyl dicarbonate; In tetrahydrofuran; at -78 - 20 ℃; for 2h;

upstream raw materials:

α-picoline

di-tert-butyl dicarbonate

Refernces

• 1、 -. "SUBSTITUTED HETEROAROMATIC PYRAZOLE-CONTAINING CARBOXAMIDE AND UREA DERIVATIVES AS VANILLOID RECEPTOR LIGANDS". Page/Page column 125. . Retrieved 2013/03/26.