150059-62-4

Basic information

• Product Name: Pyridin-2-yl-acetic acid tert-butyl ester
• Synonyms: Pyridin-2-yl-acetic acid tert-butyl ester;tert-Butyl 2-(pyridin-2-yl)acetate
• CAS NO: 150059-62-4
• Molecular Formula: C₁₁H₁₅NO₂
• Molecular Weight: 193.24
• Mol File: 150059-62-4.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 257.8±15.0 °C(Predicted)
• Appearance: /
• Density: 1.044±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.36±0.12(Predicted)
• CAS DataBase Reference: Pyridin-2-yl-acetic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridin-2-yl-acetic acid tert-butyl ester(150059-62-4)
• EPA Substance Registry System: Pyridin-2-yl-acetic acid tert-butyl ester(150059-62-4)

Safety Data

• Hazardous Substances Data: 150059-62-4(Hazardous Substances Data)

Usage

General Description

Pyridin-2-yl-acetic acid tert-butyl ester is a chemical compound with the molecular formula C12H17NO2. It is a tert-butyl ester derivative of pyridine-2-yl-acetic acid and is commonly used in organic chemistry as a reagent for various synthetic reactions. The compound has a yellowish appearance and is insoluble in water, but soluble in organic solvents. It is often employed in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals due to its versatile reactivity and ability to participate in a range of reactions including esterification, amidation, and nucleophilic substitution. Pyridin-2-yl-acetic acid tert-butyl ester is typically handled and stored in a well-ventilated area, away from heat and sources of ignition, due to its flammability and potential health hazards if not used properly.

Upstream product

• 109-99-9 tetrahydrofuran 
• 107263-95-6 N-fluoropyridinium triflate 
• 16179-97-8 pyridin-2-yl acetic acid hydrochloride 
• 75-65-0 tert-butyl alcohol 
• 109-09-1 2-chloropyridine 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 1658-42-0 methyl 2-pyridylacetate 
• 24424-99-5 di-tert-butyl dicarbonate 
• 109-06-8 α-picoline 
• 1116-98-9 cyanoacetic acid tert-butyl ester 
• 74-86-2 acetylene 
• 109-04-6 2-bromo-pyridine 
• 1207973-75-8 lithium tert-butyl acetate 
• 110-86-1 pyridine 

Downstream Products

• 90005-61-1 2-(pyridin-2-yl)propanoic acid 
• 1419596-68-1 N-((3-tert-butyl-1-(3-chlorophenyl)-1H-pyrazol-5-yl)methyl)-2-(pyridin-2-yl)propanamide 
• 1419596-72-7 N-((1-(3-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-5-yl)methyl)-2-(pyridin-2-yl)propanamide 
• 1430074-89-7 tert-butyl 3-phenylimidazo[1,5-α]pyridine-1-carboxylate 
• 1428552-42-4 tert-butyl 3-phenylindolizine-1-carboxylate 

Relevant articles and documents

MACROCYCLIC INHIBITORS OF PEPTIDYLARGININE DEIMINASES

The present disclosure relates to novel compounds for use in therapeutic treatement of a disease associated with peptidylarginine deiminases (PADs), such as peptidylarginine deiminase type 4 (PAD4). The present disclosure also relates to processes and intermediates for the preparation of such compounds, methods of using such compounds and pharmaceutical compositions comprising the compounds described herein.

Catalyst-Free Annulation of 2-Pyridylacetates and Ynals with Molecular Oxygen: An Access to 3-Acylated Indolizines

A catalyst and additive-free annulation of 2-pyridylacetates and ynals under molecular oxygen was the first developed, affording 3-acylated indolizines in good to excellent yields. Molecular oxygen was used as the source of the carbonyl oxygen atom in indolizines. This approach was compatible with a wide range of functional groups, and especially it has been successfully extended to unsaturated double bonds and triple bonds, which were difficult to prepare by previous methods in a single step.

External-Photocatalyst-Free Visible-Light-Mediated Synthesis of Indolizines

A visible-light-mediated synthesis of valuable polycyclic indolizine heterocycles from easily accessed brominated pyridine and enol carbamate derivatives has been developed. This process, which operates at room temperature under irradiation from readily available light sources, does not require the addition of an external photocatalyst. Instead, an investigation into the reaction mechanism indicates that the indolizine products themselves may be in some way involved in mediating and accelerating their own formation. Preliminary studies also show that these simple heterocyclic compounds may be capable of facilitating other visible-light-mediated transformations.