Pentiapine

Base Information

• Chemical Name: Pentiapine
• CAS No.: 81382-51-6
• Molecular Formula: C₁₅H₁₇N₅S
• Molecular Weight: 299.399
• Mol file: 81382-51-6.mol

Synonyms:Pentiapine;5-(4-Methyl-1-piperazinyl)imidazo[2,1-b][1,3,5]benzothiadiazepine

Chemical Property of Pentiapine

Chemical Property:

• Melting Point: 141-144 °C(Solv: isopropanol (67-63-0))
• Boiling Point: 548.2±60.0 °C(Predicted)
• PKA: 7.21±0.42(Predicted)
• PSA: 61.96000
• Density: 1.38±0.1 g/cm3(Predicted)
• LogP: 1.44230

Purity/Quality:

99% ^*data from raw suppliers

Pentiapine 99.74% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pentiapine

There total 13 articles about Pentiapine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

1-methyl-piperazine (109-01-3) + 5-methylthioimidazo<2,1-b><1,3,5>benzothiadiazepine (81407-59-2) → Pentiapine (81382-51-6)

Guidance literature:

With N-methylpiperazine dihydrochloride; In pentan-1-ol; for 48h; Heating;

DOI:10.1002/jhet.5570200528

Reference yield:

5-(4-carboethoxypiperazino)-imidazo[2,1-b][1,3,5]benzothiadiazepine (81382-78-7) → Pentiapine (81382-51-6)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran;

Reference yield:

5-(4H-1-piperazinyl)imidazo<2,1-b><1,3,5>benzothiadiazepine (81382-70-9) + methyl iodide (74-88-4) → Pentiapine (81382-51-6)

Guidance literature:

With potassium carbonate; In water; acetone;

upstream raw materials:

1-methyl-piperazine

5-cyanothioimidazo<2,1-b><1,3,5>benzothiadiazepine

5-methylthioimidazo<2,1-b><1,3,5>benzothiadiazepine

bromocyane

Refernces

• 1、 -. "5(1-Piperazinyl(imidazo[2,1-b][1,3,5]benzothiadiazepines". . . Retrieved 2008/06/13.