A 967079

Base Information

Chemical Name:A 967079
CAS No.:1170613-55-4
Molecular Formula:C12H14FNO
Molecular Weight:207.248
Hs Code.:2928000090
Mol file:1170613-55-4.mol

Synonyms:A 967079;(1E,3E)-1-(4-Fluorophenyl)-2-Methyl-1-penten-3-one oxiMe

Suppliers and Price of A 967079

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
A 967079
10mg
$ 403.00

TRC
(1E,3E)-1-(4-Fluorophenyl)-2-methyl-1-penten-3-oneOxime
100mg
$ 925.00

Tocris
A967079 ≥98%(HPLC)
50
$ 670.00

Tocris
A967079 ≥98%(HPLC)
10
$ 162.00

Sigma-Aldrich
A-967079 ≥98% (HPLC)
25mg
$ 451.00

Sigma-Aldrich
A-967079 ≥98% (HPLC)
5mg
$ 118.00

CSNpharm
A967079
100mg
$ 512.00

CSNpharm
A967079
25mg
$ 167.00

CSNpharm
A967079
10mg
$ 74.00

CSNpharm
A967079
5mg
$ 47.00

Total 13 raw suppliers

Chemical Property of A 967079

Chemical Property:

Boiling Point:324.4±34.0 °C(Predicted)
PKA:12.23±0.40(Predicted)
PSA：32.59000
Density:1.03±0.1 g/cm3 (20 ºC 760 Torr)
LogP:3.46920
Storage Temp.:2-8°C
Solubility.:DMSO: ≥12mg/mL

Purity/Quality:

99%, ^*data from raw suppliers

A 967079 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description A-967079 (1170613-55-4) is a TRPA1 blocker. Active in rat models.1 Cell permeable
Uses (1E,3E)- 1-(4-Fluorophenyl)-2-methyl-1-penten-3-one Oxime is a transient receptor potential ankyrin 1 (TRPA1) antagonist and has been investigated as potential analgesic drug for the treatment of chronic pain. A-967079 has been used in blocking miR-711-induced TRPA1 (transient receptor potential cation channel subfamily A member 1) channel.

Technology Process of A 967079

There total 5 articles about A 967079 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1170613-81-6
(E)-1-(4-fluorophenyl)-2-methylpent-1-en-3-one

: 1170613-55-4,1357350-70-9
A-967079

Guidance literature:: With hydroxylamine hydrochloride; In pyridine;

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 1170613-55-4,1357350-70-9
A-967079

Guidance literature:: Multi-step reaction with 4 steps

1: toluene / Reflux

2: isopropylmagnesium chloride / tetrahydrofuran / 2 h / 0 °C

3: tetrahydrofuran / 3 h / -20 - 0 °C

4: pyridine; hydroxylamine hydrochloride / 2 h / 20 °C

With pyridine; hydroxylamine hydrochloride; isopropylmagnesium chloride; In tetrahydrofuran; toluene;

Reference yield:

: 134294-41-0
ethyl 3-(4-fluorophenyl)-2-methyl-2-propenoate

: 1170613-55-4,1357350-70-9
A-967079

Guidance literature:: Multi-step reaction with 3 steps

1: isopropylmagnesium chloride / tetrahydrofuran / 2 h / 0 °C

2: tetrahydrofuran / 3 h / -20 - 0 °C

3: pyridine; hydroxylamine hydrochloride / 2 h / 20 °C

With pyridine; hydroxylamine hydrochloride; isopropylmagnesium chloride; In tetrahydrofuran;