134294-41-0

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 21382-82-1 (carbethoxyethylidene)triphenylphosphorane 
• 459-45-0 4-fluorobenzenediazonium tetrafluoroborate 
• 80-62-6 methacrylic acid methyl ester 
• 3699-66-9 ethyl 2-diethoxyphosphorylpropionate 
• 535-11-5 Ethyl 2-bromopropionate 

Downstream Products

• 125265-16-9 3-(4-fluorophenyl)-2-methyl-2-propen-1-al 
• 1000995-66-3 (E)-3-(4-fluorophenyl)-2-methylprop-2-en-1-ol 
• 22138-72-3 (E)-3-(4-fluorophenyl)-2-methylacrylic acid 
• 1170613-78-1 (E)-3-(4-fluorophenyl)-N-methoxy-N,2-dimethylacrylamide 
• 1170613-81-6 (E)-1-(4-fluorophenyl)-2-methylpent-1-en-3-one 
• 1170613-57-6 (1E,3E)-1-(4-fluorophenyl)-2-methylpent-1-en-3-one O-methyloxime 
• 1170613-55-4 A-967079 
• 1170613-61-2 (1E,3E)-1-(4-fluorophenyl)-2-methylhex-1-en-3-one oxime 
• 1170613-90-7 (E)-1-(4-fluorophenyl)-2-methylhex-1-en-3-one 
• 1170613-63-4 (1E,3E)-1-(4-fluorophenyl)-2,4,4-trimethylpent-1-en-3-one oxime 
• 1170613-92-9 (E)-1-(4-fluorophenyl)-2,4,4-trimethylpent-1-en-3-one 
• 1170613-65-6 (1E,3E)-1-(4-fluorophenyl)-2-methylhept-1-en-3-one oxime 
• 1170613-95-2 (E)-1-(4-fluorophenyl)-2-methylhept-1-en-3-one 
• 1170613-66-7 (1E,3Z)-1-(4-fluorophenyl)-2,4-dimethylpent-1-en-3-one oxime 

Relevant academic research and scientific papers

Copper-Photocatalyzed Contra-Thermodynamic Isomerization of Polarized Alkenes

The contra-thermodynamic isomerization of α- and β-substituted cinnamate derivatives catalyzed by the Cu(OAc)2/rac-BINAP complex under blue light irradiation is reported. The use of an oxazolidinone template, which favored the complexation of the copper catalyst to the substrate, allowed the E → Z isomerization of the catalytically formed chromophore under simple and robust reaction conditions in good to excellent ratios. The mechanism of this process based on the transient formation of a chromophore was also studied.

Asymmetric Nazarov Cyclizations of Unactivated Dienones by Hydrogen-Bond-Donor/Lewis Acid Co–Catalyzed, Enantioselective Proton-Transfer

We report an enantioselective Nazarov cyclization catalyzed by chiral hydrogen-bond-donors in concert with silyl Lewis acids. The developed transformation provides access to tri-substituted cyclopentenones in high levels of enantioselectivity (up to 95% e.e.) from a variety of simple unactivated dienones. Kinetic and mechanistic studies are consistent with a reversible 4π-electrocyclization C?C bond-forming step followed by rate- and enantio-determining proton-transfer as the mode of catalysis. (Figure presented.).

Pd-Catalyzed α-Selective C-H Functionalization of Olefins: En Route to 4-Imino-β-Lactams

Pd-catalyzed α-olefinic C-H activation of simple α,β-unsaturated olefins has been developed. 4-imino-β-lactam derivatives were readily synthesized via activation of α-olefinic C-H bonds with excellent cis stereoselectivity. A wide range of heterocycles at the β-position are compatible with this reaction. The product of 4-imino-β-lactam derivatives can be readily converted to 2-aminoquinoline which exists extensively in pharmaceutical drugs and natural products.

TRPA1 antagonists

Compounds of formula (I) wherein R1, R2, R3, m, and Y are defined in the specification are TRPA1 antagonists. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds

Highly enantioselective hydrogenation of 2-substituted-2-alkenols catalysed by a ChenPhos-Rh complex

Highly enantioselective hydrogenation of a variety of 2-substituted-2- alkenols has been achieved using a ChenPhos-Rh complex as catalyst, giving ≥99% ee for most substrates. Optically active antifungal agent amorolfine was first synthesised using hydrogenation as the key step. This journal is

Arenediazonium salts immobilized in imidazolium ionic liquids as electrophilic partners in the Pd(OAc)2-catalyzed Matsuda-Heck arylation

The utility of arenediazonium salts immobilized in imidazolium-ILs [BMIMPF6 and BMIMBF4] for facile, high yielding, synthesis of olefins via the Pd(OAc)2-catalyzed Matsuda-Heck arylation reaction has been demonstrated. The reaction can also be performed as a two-step process in the IL starting from ArNH2, by sequential in-situ diazotization-arylation. Simple product isolation and the recycling/re-use of the IL are additional advantages of this one-pot method.

Chromatography-free wittig reactions using a bifunctional polymeric reagent

The first example of a polystyrene bearing two distinct reagent groups has been prepared. This phosphine and amine functionalized material was used in one-pot Wittig reactions with an aldehyde and either an α-halo-ester, -ketone, or -amide. Due to the heterogeneous nature of the polymer, the desired alkene product of these reactions could be isolated in excellent yield in essentially pure form after only filtration and solvent removal.

TRPA1 Antagonists

Compounds of formula (I) wherein R1, R2, R3, m, and Y are defined in the specification are TRPA1 antagonists. Compositions comprising such compounds and methods for treating conditions and disorders using such compounds an

Vanadium-catalyzed asymmetric epoxidation of allylic alcohols in water

Asymmetric V-catalyzed epoxidation of allylic alcohols can be carried out in water with chiral ligands, which incorporate sulfonamide and hydroxamic acid fragments. Furthermore, the reaction, notorious for its ligand-deceleration effect, in water turned into the ligand-accelerated process. By using this aqueous protocol, a range of allylic alcohols were epoxidized with up to 94% ee.

INHIBITORS OF HUMAN TUMOR-EXPRESSED CCXCKR2

Pharmaceutical compositions containing organic compounds or salts thereof that serve as modulators for the SDF-1 or I-TAC chemokines are disclosed. The compounds and compositions are useful in the treatment of cancer, especially in the inhibition of cancer proliferation, growth, and metastasis. Methods of interfering with SDF-1 and/or I-TAC binding to the CCXCKR2 receptor and treating cancer using the compounds and pharmaceutical compositions of the present invention are also disclosed.