ACHN 975

Base Information

Chemical Name:ACHN 975
CAS No.:1410809-36-7
Molecular Formula:C₂₀H₂₃N₃O₄
Molecular Weight:369.42
Hs Code.:
Mol file:1410809-36-7.mol

Synonyms:ACHN 975

Suppliers and Price of ACHN 975

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of ACHN 975

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ACHN 975

There total 8 articles about ACHN 975 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: 1427677-01-7
N-((S)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl)-4-(((1R,2R)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamide

: 1410809-36-7
N-((S)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl)-4-(((1R,2R)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamide

Guidance literature:: With sodium carbonate; In 2-methyltetrahydrofuran; water; pH=8 - 9;

Reference yield:

: (4R,5R)-diisopropyl 2-((1R,2R)-2-(acetoxymethyl)cyclopropyl)-1,3-dioxolane-4,5-dicarboxylate

: 1410809-36-7
N-((S)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl)-4-(((1R,2R)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic acid / 2 h / 80 °C

2.1: triphenylphosphine / dichloromethane / 1.5 h / -78 - 20 °C / Inert atmosphere

3.1: bis(dibenzylideneacetone)-palladium⁽⁰⁾; Tri(p-tolyl)phosphine; triethylamine / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

4.1: sodium hydroxide / tetrahydrofuran; water / 8 h / 20 °C

5.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 5 h / 20 °C

6.1: hydrogenchloride / methanol

7.1: hydroxylamine hydrochloride / tetrahydrofuran; water; isopropyl alcohol / 0 - 5 °C / Cooling with ice

7.2: 0 °C

8.1: sodium carbonate / water; 2-methyltetrahydrofuran / pH 8 - 9

With hydrogenchloride; hydroxylamine hydrochloride; sodium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; Tri(p-tolyl)phosphine; sodium hydroxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; 2-methyltetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: (S)-methyl-3-amino-2-(4-(((1R,2R)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamido)-3-methylbutanoate hydrochloride

: 1410809-36-7
N-((S)-3-amino-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl)-4-(((1R,2R)-2-(hydroxymethyl)cyclopropyl)buta-1,3-diynyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydroxylamine hydrochloride / tetrahydrofuran; water; isopropyl alcohol / 0 - 5 °C / Cooling with ice

1.2: 0 °C

2.1: sodium carbonate / water; 2-methyltetrahydrofuran / pH 8 - 9

With hydroxylamine hydrochloride; sodium carbonate; In tetrahydrofuran; 2-methyltetrahydrofuran; water; isopropyl alcohol;