methyl 4-(((1 R,2R)-2-(acetoxymethyl)cyclopropyl)buta-1,3-diynyl)benzoate

Base Information

Chemical Name:methyl 4-(((1 R,2R)-2-(acetoxymethyl)cyclopropyl)buta-1,3-diynyl)benzoate
CAS No.:1410809-80-1
Molecular Formula:C₁₈H₁₆O₄
Molecular Weight:296.323
Hs Code.:

Synonyms:methyl 4-(((1 R,2R)-2-(acetoxymethyl)cyclopropyl)buta-1,3-diynyl)benzoate

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Chemical Property of methyl 4-(((1 R,2R)-2-(acetoxymethyl)cyclopropyl)buta-1,3-diynyl)benzoate

Chemical Property:

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Technology Process of methyl 4-(((1 R,2R)-2-(acetoxymethyl)cyclopropyl)buta-1,3-diynyl)benzoate

There total 9 articles about methyl 4-(((1 R,2R)-2-(acetoxymethyl)cyclopropyl)buta-1,3-diynyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.5%

: 1410809-79-8
((1R,2R)-2-(2,2-dibromovinyl)cyclopropyl)methyl acetate

: 3034-86-4
4-ethynylbenzoic acid methyl ester

: 1410809-80-1
methyl 4-(((1 R,2R)-2-(acetoxymethyl)cyclopropyl)buta-1,3-diynyl)benzoate

Guidance literature:: With triethylamine; Tri(p-tolyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 20 ℃; for 5h; Inert atmosphere;
DOI:10.1002/cmdc.201900287

Reference yield:

: 1410809-78-7,397274-64-5
((1R,2R)-2-formylcyclopropyl)methyl acetate

: 1410809-80-1
methyl 4-(((1 R,2R)-2-(acetoxymethyl)cyclopropyl)buta-1,3-diynyl)benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine / dichloromethane / 2 h / -78 - 20 °C / Inert atmosphere

2: triethylamine / Tri(p-tolyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

With triethylamine; triphenylphosphine; Tri(p-tolyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 38982-39-7
acetic acid trans-4-oxo-but-2-enyl ester

: 1410809-80-1
methyl 4-(((1 R,2R)-2-(acetoxymethyl)cyclopropyl)buta-1,3-diynyl)benzoate

Guidance literature:: Multi-step reaction with 6 steps

1: ammonium nitrate / ethanol / 15 h / 20 °C

2: pyridinium p-toluenesulfonate / benzene / 15 h / 90 °C

3: diethylzinc / hexane / 8 h / -20 - 20 °C / Inert atmosphere

4: acetic acid / 2 h / 80 °C

5: triphenylphosphine / dichloromethane / 2 h / -78 - 20 °C / Inert atmosphere

6: triethylamine / Tri(p-tolyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / N,N-dimethyl-formamide / 5 h / 20 °C / Inert atmosphere

With diethylzinc; acetic acid; triethylamine; triphenylphosphine; ammonium nitrate; pyridinium p-toluenesulfonate; Tri(p-tolyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In ethanol; hexane; dichloromethane; N,N-dimethyl-formamide; benzene;