Methyl Salicylate β-D-O-Glucuronide Triacetate Methyl Ester

Base Information

• Chemical Name: Methyl Salicylate β-D-O-Glucuronide Triacetate Methyl Ester
• CAS No.: 101231-54-3
• Molecular Formula: C₂₁H₂₄O₁₂
• Molecular Weight: 468.414
• Mol file: 101231-54-3.mol

Synonyms:Methyl Salicylate β-D-O-Glucuronide Triacetate Methyl Ester;2-(Methoxycarbonyl)phenyl β-D-Glucopyranosiduronic Acid Methyl Triacetate;2-(Methoxycarbonyl)phenyl beta-D-glucopyranosiduronic acid methyl ester triacetate

Chemical Property of Methyl Salicylate β-D-O-Glucuronide Triacetate Methyl Ester

Chemical Property:

• Melting Point: 176-178 °C(Solv: methanol (67-56-1))
• Boiling Point: 528.7±50.0 °C(Predicted)
• PSA: 149.96000
• Density: 1.35±0.1 g/cm3(Predicted)
• LogP: 0.54500
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

MethylSalicylateβ-D-O-GlucuronideTriacetateMethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the synthesis of Aspirin metabolite.

Technology Process of Methyl Salicylate β-D-O-Glucuronide Triacetate Methyl Ester

There total 2 articles about Methyl Salicylate β-D-O-Glucuronide Triacetate Methyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester (21085-72-3) + methyl salicylate (119-36-8,8024-54-2) → O2,O3,O4-triacetyl-O1-(2-methoxycarbonyl-phenyl)-β-D-glucopyranuronic acid methyl ester (101231-54-3)

Guidance literature:

With quinoline; silver(l) oxide;

DOI:10.1248/cpb1953.5.570

Reference yield:

→ O2,O3,O4-triacetyl-O1-(2-methoxycarbonyl-phenyl)-β-D-glucopyranuronic acid methyl ester (101231-54-3)

Guidance literature:

2,3,4-Tri-O-acetyl-1-brom-β-D-glucuronsaeure-methylester, Salicylsaeure-methyl-ester in Isochinolin ;

Reference yield:

O2,O3,O4-triacetyl-O1-(2-methoxycarbonyl-phenyl)-β-D-glucopyranuronic acid methyl ester (101231-54-3) → Salicylic acid phenol glucuronide (7695-70-7,31566-22-0,7696-34-6,96750-93-5)

Guidance literature:

With barium dihydroxide; water;

DOI:10.1021/jo01111a603

upstream raw materials:

1-bromo-2,3,4-tri-O-acetyl-α-D-glucuronic acid methyl ester

methyl salicylate

Downstream raw materials:

Salicylic acid phenol glucuronide

Refernces