tert-butyl 2-(4-(1-methyl-1H-imidazol-4-ylamino)-6-chloro-1,3,5-triazin-2-ylamino)-2-(4-fluorophenyl)ethylcarbamate

Base Information

Chemical Name:tert-butyl 2-(4-(1-methyl-1H-imidazol-4-ylamino)-6-chloro-1,3,5-triazin-2-ylamino)-2-(4-fluorophenyl)ethylcarbamate
CAS No.:1200606-41-2
Molecular Formula:C₂₀H₂₄ClFN₈O₂
Molecular Weight:0
Hs Code.:
Mol file:1200606-41-2.mol

Synonyms:tert-butyl 2-(4-(1-methyl-1H-imidazol-4-ylamino)-6-chloro-1,3,5-triazin-2-ylamino)-2-(4-fluorophenyl)ethylcarbamate

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Chemical Property of tert-butyl 2-(4-(1-methyl-1H-imidazol-4-ylamino)-6-chloro-1,3,5-triazin-2-ylamino)-2-(4-fluorophenyl)ethylcarbamate

Chemical Property:

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Technology Process of tert-butyl 2-(4-(1-methyl-1H-imidazol-4-ylamino)-6-chloro-1,3,5-triazin-2-ylamino)-2-(4-fluorophenyl)ethylcarbamate

There total 1 articles about tert-butyl 2-(4-(1-methyl-1H-imidazol-4-ylamino)-6-chloro-1,3,5-triazin-2-ylamino)-2-(4-fluorophenyl)ethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1200605-68-0
4,6-dichloro-N-(1-methyl-1H-imidazol-4-yl)-1,3,5-triazin-2-amine

: 912762-88-0
rac-tert-butyl [2-amino-2-(4-fluorophenyl)ethyl]carbamate

: 1200606-41-2
tert-butyl [2-({4-chloro-6-[(1-methyl-1H-imidazol-4-yl)amino]-1,3,5-triazin-2-yl}amino)-2-(4-fluorophenyl)ethyl]carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 18 - 25 ℃;

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 1200606-41-2
tert-butyl [2-({4-chloro-6-[(1-methyl-1H-imidazol-4-yl)amino]-1,3,5-triazin-2-yl}amino)-2-(4-fluorophenyl)ethyl]carbamate

: 1200605-32-8
tert-butyl [2-(4-fluorophenyl)-2-({4-[(1-methyl-1H-imidazol-4-yl)amino]-6-morpholin-4-yl-1,3,5-triazin-2-yl}amino)ethyl]carbamate

Guidance literature:: In acetonitrile; at 80 ℃; for 2h;

Reference yield:

: 1200606-41-2
tert-butyl [2-({4-chloro-6-[(1-methyl-1H-imidazol-4-yl)amino]-1,3,5-triazin-2-yl}amino)-2-(4-fluorophenyl)ethyl]carbamate

: 1200605-36-2
tert-butyl [(2S)-2-(4-fluorophenyl)-2-({4-[(1-methyl-1H-imidazol-4-yl)amino]-6-morpholin-4-yl-1,3,5-triazin-2-yl}amino)ethyl]carbamate

: 1200605-34-0
tert-butyl [(2R)-2-(4-fluorophenyl)-2-({4-[(1-methyl-1H-imidazol-4-yl)amino]-6-morpholin-4-yl-1,3,5-triazin-2-yl}amino)ethyl]carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 2 h / 80 °C

2: CHIRALPAK AD column / methanol; ethanol / 18 - 25 °C / Resolution of racemate

With CHIRALPAK AD column; In methanol; ethanol; acetonitrile;